[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy]

[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy] Abstract Text:

Yoichi Sakurai,Shinpei Furuta,Risaburo Sunagawa,Shuhei Tonomura,Kazuki Inaba,Mitsutaka Shoji,Yasuko Nakamura,Jun Isogaki,Yoshiyuki Komori,Ichiro Uyama,Shingo Kamoshida,Yutaka Tsutsumi,Yoichi Sakurai,Shinpei Furuta,Risaburo Sunagawa,Shuhei Tonomura,Kazuki Inaba,Mitsutaka Shoji,Yasuko Nakamura,Jun Isogaki,Yoshiyuki Komori,Ichiro Uyama,Shingo Kamoshida,Yutaka Tsutsumi,

Orotate phosphoribosyltransferase (OPRT, EC 2.4.2.10), a key enzyme that catalyzes one of the primary first-step phosphorylation processes of fluoropyrimidine, has recently been recognized as an important factor that primarily determines the anticancer effects of S-1. The OPRT levels were examined in 97 gastric carcinoma tissues and 65 normal gastric mucosa tissues obtained from patients with gastric carcinoma using a newly-developed enzyme-linked immunosorbent assay. Correlations with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the effects of neoadjuvant chemotherapy were evaluated. The OPRT level in gastric carcinoma tissue was significantly higher than that in normal gastric mucosa. There was no correlation of OPRT level with either TS or DPD levels. There was no correlation of OPRT level between those in gastric carcinoma and those in normal gastric mucosa simultaneously obtained from identical patients. The OPRT levels in patients who underwent neoadjuvant chemotherapy were not different from those without neoadjuvant chemotherapy. These results suggest that activation of fluoropyrimidine mainly occurs in carcinoma tissues and the OPRT levels in carcinoma tissues were not influenced by neoadjuvant chemotherapy with fluoropyrimidine.

[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy] Publishing Authors By Initials

Y Sakurai,S Furuta,R Sunagawa,S Tonomura,K Inaba,M Shoji,Y Nakamura,J Isogaki,Y Komori,I Uyama,S Kamoshida,Y Tsutsumi,Y Sakurai,S Furuta,R Sunagawa,S Tonomura,K Inaba,M Shoji,Y Nakamura,J Isogaki,Y Komori,I Uyama,S Kamoshida,Y Tsutsumi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gan to kagaku ryoho. Cancer & chemotherapy

VOLUME: 34

Page Numbers: 1581-7

Journal Abbreviation: Gan To Kagaku Ryoho

ISSN: 0385-0684

DAY: 17

MONTH: Oct

YEAR: 2007

[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy] Information

Number of References:

LANGUAGE: jpn

NlmUniqueID: 7810034

[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy]

AFFILIATION: Dept. of Surgery, Fujita Health University School of Medicine.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Gan To Kagaku Ryoho

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy Related Publications

• "A brownish depressed area": a novel narrow band imaging colonoscopic finding of a depressed adenoma.
• 3D morphological assessment of occlusal treatment by measuring dental casts with a micro-focus X-ray CT.
• Arabidopsis ELONGATED MITOCHONDRIA1 Is Required for Localization of DYNAMIN-RELATED PROTEIN3A to Mitochondrial Fission Sites.
• Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts.
• Comparative study on transduction and toxicity of protein transduction domains.
• Comparison between properties of 2'-O,4'-C-ethylene-bridged nucleic acid (ENA) phosphorothioate oligonucleotides and N3'-P5' thiophosphoramidate oligonucleotides.
• DO-increasing effects of a microscopic bubble generating system in a fish farm.
• Deposition of IgD, alpha-1-antitrypsin and alpha-1-antichymotrypsin on Demodex folliculorum and D. brevis infesting the pilosebaceous unit.
• Double outlet right ventricle with intact ventricular septum.
• Effects of Combined Administration of DPD-Inhibitory Oral Fluoropyrimidine, S-1, Plus Paclitaxel on Gene Expressions of Fluoropyrimidine Metabolism-Related Enzymes in Human Gastric Xenografts.
• Histochemical identification of methicillin-resistant Staphylococcus aureus: contribution to preventing nosocomial infection.
• Histochemical study on enzymes of cancer cells in ascites.
• Histological examination of PLGA nanospheres for intratracheal drug administration.
• Histopathological diagnosis of infectious diseases using patients' sera.
• Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide.
• Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues.
• Localization of Epstein-Barr virus in lymph node metastasis with nasopharyngeal carcinoma.
• MRI analysis of structural changes in skeletal muscles and surrounding tissues following long-term walking exercise with training equipment.
• Optimization of protein therapies by polymer-conjugation as an effective DDS.
• Organelle-targeted delivery of biological macromolecules using the protein transduction domain: potential applications for Peptide aptamer delivery into the nucleus.
• Penetration by bull spermatozoa into the zona pellucida of dead bovine oocytes recovered from frozen-thawed ovaries.
• Pulse wave velocity and ankle brachial index in patients with Kawasaki disease.
• Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity.
• Transdermal delivery of insulin using trypsin as a biochemical enhancer.
• [Laboratory and clinical studies on methacycline (Rondomycin Pfizer)]
• [On the effects of glucuronic acid preparations and various drugs on the formation of antibodies to diphtheria toxin.]
• [Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy]
• [Predictive value of orotate phosphoribosyltransferase in chemoresistant patients with gastric carcinoma who underwent s-1-based neoadjuvant/adjuvant chemotherapy.]
• [Purification and properties of a growth factor from human bone matrix]
• [Rs virus and respiratory tract diseases.]