Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey.

Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey. Research Abstract Details 

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Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey. Abstract Text:

P Wallén,O Shupliakov,R H Hill,

The periodic membrane potential fluctuations in motoneurons during fictive locomotion in the lamprey, a primitive vertebrate, involve phasic synaptic excitation and inhibition. This paper investigates the origin of the phasic synaptic input to lamprey myotomal motoneurons in the in vitro spinal cord preparation with regard to the relative contribution of descending propriospinal input from interneurons in the local segment. The synaptic drive to myotomal motoneurons in the most rostral and the most caudal part of the spinal cord preparation are compared before and after selective spinal cord lesions. Current clamp recordings of the same cell before and after lesion showed that neither the excitatory phase nor the inhibitory phase was abolished after interruption of the descending or the ascending ipsilateral input, or after interrupting crossing segmental input by a local longitudinal midline incision. None of these sources thus appears to be alone responsible for the phasic synaptic drive. To quantitatively evaluate these effects, and in particular the contribution from the descending propriospinal fibres to the inhibitory phase, voltage clamp recordings were made in combination with a spinal cord hemisection just rostral to the motoneuron. The input from propriospinal interneurons in approximately 15 rostral segments may be responsible for as much as 70% of the phase of inhibitory current during the locomotor cycle. In accordance with these findings, a similar voltage clamp analysis of rostrally and caudally located motoneurons showed that the average peak-to-peak amplitude of the current fluctuations in rostral cells was approximately 50% of that in caudal cells.

Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey. Publishing Authors By Initials

P Wallén,O Shupliakov,RH Hill,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 96

Page Numbers: 194-202

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1993

Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey. Information

Substance Name: lucifer yellow

Registry Number: 77944-88-8

Grant and Affiliation Information for Origin of phasic synaptic inhibition in myotomal motoneurons during fictive locomotion in the lamprey.

AFFILIATION: Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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