Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase.

Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. Research Abstract Details 

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Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. Abstract Text:

Y Seyama,T Kasama,T Yamakawa,A Kawaguchi,K Saito,

The mechanism of hydrogen incorporation into fatty acids was investigated with an enzyme preparation from baker's yeast. Fatty acids synthesized from malonyl-CoA and acetyl-CoA in the presence of D2O or stereospecifically deuterium-labeled NADPH were isolated and analyzed by mass chromatography to examine the localization of deuterium atoms in the molecule. The following results were obtained: 1. Hydrogen atoms from water were found on the even-numbered methylene carbon atoms (2-hydrogen atoms per carbon atom). The second hydrogen atom was incorporated as the result of hydrogen exchange phenomenon between the methylene group of malonyl CoA and water. 2. HB hydrogen of NADPH was used for beta-ketoacyl reductase. 3. HB hydrogen of NADPH was also used for enoyl reductase. 4. Hydrogen atoms from HB position of NADPH were found on the odd-numbered methylene carbon atoms (2-hydrogen atoms per carbon atom).

Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. Publishing Authors By Initials

Y Seyama,T Kasama,T Yamakawa,A Kawaguchi,K Saito,

For similar lipids: fatty acids: stearic acids research abstracts see: lipids: fatty acids: stearic acids research

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Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 82

Page Numbers: 1325-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Nov

YEAR: 1977

Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. Keywords Mesh Terms:

KEYWORDS: Stearic Acids

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. Information

Substance Name: Fatty Acid Synthetase Complex

Registry Number: EC 6.-

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Country: JAPAN

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MEDLINETA: J Biochem

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