Both the X and Y chromosomes have a remarkable enrichment of genes involved in gonadogenesis and gametogenesis. The small Y chromosome contains the sex determining gene SRY, as well as many genes that are critical for spermatogenesis and are expressed exclusively in the testis. The X chromosome, too, is enriched for genes involved in sex and reproduction. This biased gene content can be best understood in terms of the origin and evolution of our sex chromosomes. The Y chromosome can be seen as the relic of the ancient autosome, on which only a few genes survive by virtue of their critical male-specific role. The X is more complicated - it has evolved male-advantage genes because of its representation as a single copy in males, where it is exposed to selection for male-advantage genes.
Origin and evolution of spermatogenesis genes on the human sex chromosomes. Publishing Authors By Initials
Origin and evolution of spermatogenesis genes on the human sex chromosomes. Journal Published:
PUBLICATION TYPE: Review
Journal: Society of Reproduction and Fertility supplement
VOLUME: 65
Page Numbers: 1-17
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DAY: 19
MONTH: 11
YEAR: 2007
Origin and evolution of spermatogenesis genes on the human sex chromosomes. Information
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LANGUAGE: eng
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Origin and evolution of spermatogenesis genes on the human sex chromosomes. Keywords Mesh Terms:
KEYWORDS: Spermatogenesis
MESH TERMS: genetics
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Grant and Affiliation Information for Origin and evolution of spermatogenesis genes on the human sex chromosomes.
AFFILIATION: Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra ACT 2601, Australia. Margaret.Delbridge@anu.edu.au
Country: England
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MEDLINETA: Soc Reprod Fertil Suppl
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