Origin and evolution of human microRNAs from transposable elements.

Origin and evolution of human microRNAs from transposable elements. Research Abstract Details 

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Origin and evolution of human microRNAs from transposable elements. Abstract Text:

Jittima Piriyapongsa,Leonardo ,I King Jordan,

We sought to evaluate the extent of the contribution of transposable elements (TEs) to human microRNA (miRNA) genes along with the evolutionary dynamics of TE-derived human miRNAs. We found 55 experimentally characterized human miRNA genes that are derived from TEs, and these TE-derived miRNAs have the potential to regulate thousands of human genes. Sequence comparisons revealed that TE-derived human miRNAs are less conserved, on average, than non-TE-derived miRNAs. However, there are 18 TE-derived miRNAs that are relatively conserved, and 14 of these are related to the ancient L2 and MIR families. Comparison of miRNA vs. mRNA expression patterns for TE-derived miRNAs and their putative target genes showed numerous cases of anti-correlated expression that are consistent with regulation via mRNA degradation. In addition to the known human miRNAs that we show to be derived from TE sequences, we predict an additional 85 novel TE-derived miRNA genes. TE sequences are typically disregarded in genomic surveys for miRNA genes and target sites; this is a mistake. Our results indicate that TEs provide a natural mechanism for the origination miRNAs that can contribute to regulatory divergence between species as well as a rich source for the discovery of as yet unknown miRNA genes.

Origin and evolution of human microRNAs from transposable elements. Publishing Authors By Initials

J Piriyapongsa,L ,IK Jordan,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

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Origin and evolution of human microRNAs from transposable elements. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genetics

VOLUME: 176

Page Numbers: 1323-37

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 15

MONTH: 04

YEAR: 2007

Origin and evolution of human microRNAs from transposable elements. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374636

Origin and evolution of human microRNAs from transposable elements. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: genetics

Chemical & Substance for Abstract: Origin and evolution of human microRNAs from transposable elements. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Origin and evolution of human microRNAs from transposable elements.

AFFILIATION: School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Country: United States

AGENCY: United States PHS

GRANT: NIH0011392375

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MEDLINETA: Genetics

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