Organ cross talk modulates pelvic pain.

Organ cross talk modulates pelvic pain. Research Abstract Details 

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Organ cross talk modulates pelvic pain. Abstract Text:

Charles N Rudick,Michael C Chen,Anne K Mongiu,David J Klumpp,

Interstitial cystitis (IC) is a chronic bladder inflammatory disease of unknown etiology that is often regarded as a neurogenic cystitis. IC is associated with urothelial lesions, voiding dysfunction, and pain in the pelvic/perineal area, and diet can exacerbate IC symptoms. In this study, we used a murine neurogenic cystitis model to investigate the development of pelvic pain behavior. Neurogenic cystitis was induced by the injection of Bartha's strain of pseudorabies virus (PRV) into the abductor caudalis dorsalis tail base muscle of female C57BL/6J mice. Infectious PRV virions were isolated only from the spinal cord, confirming the centrally mediated nature of this neurogenic cystitis model. Pelvic pain was assessed using von Frey filament stimulation to the pelvic region, and mice infected with PRV developed progressive pelvic pain. Pelvic pain was alleviated by 2% lidocaine instillation into either the bladder or the colon but not following lidocaine instillation into the uterus. The bladders of PRV-infected mice showed markers of inflammation and increased vascular permeability compared with controls. In contrast, colon histology was normal and vascular permeability was unchanged, suggesting that development of pelvic pain was due only to bladder inflammation. Bladder-induced pelvic pain was also exacerbated by colonic administration of a subthreshold dose of capsaicin. These data indicate organ cross talk in pelvic pain and modulation of pain responses by visceral inputs distinct from the inflamed site. Furthermore, these data suggest a mechanism by which dietary modification benefits pelvic pain symptoms.

Organ cross talk modulates pelvic pain. Publishing Authors By Initials

CN Rudick,MC Chen,AK Mongiu,DJ Klumpp,

For similar virus diseases: central nervous system viral diseases: pseudorabies research abstracts see: virus diseases: central nervous system viral diseases: pseudorabies research

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MEDLINE DATE:

Organ cross talk modulates pelvic pain. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Regulatory, integr

VOLUME: 293

Page Numbers: R1191-8

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 11

MONTH: 07

YEAR: 2007

Organ cross talk modulates pelvic pain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Organ cross talk modulates pelvic pain. Keywords Mesh Terms:

KEYWORDS: Pseudorabies

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Organ cross talk modulates pelvic pain. Information

Substance Name: Capsaicin

Registry Number: 404-86-4

Grant and Affiliation Information for Organ cross talk modulates pelvic pain.

AFFILIATION: Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Ave., Chicago, IL 60611, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: T32 DK 062716-05

ACRONYM: DK

MEDLINETA: Am J Physiol Regul Integr Comp

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