Orbitofrontal cortex and its contribution to decision-making.

Orbitofrontal cortex and its contribution to decision-making. Research Abstract Details 

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Orbitofrontal cortex and its contribution to decision-making. Abstract Text:

Jonathan D Wallis,

Damage to orbitofrontal cortex (OFC) produces an unusual pattern of deficits. Patients have intact cognitive abilities but are impaired in making everyday decisions. Here we review anatomical, neuropsychological, and neurophysiological evidence to determine the neuronal mechanisms that might underlie these impairments. We suggest that OFC plays a key role in processing reward: It integrates multiple sources of information regarding the reward outcome to derive a value signal. In effect, OFC calculates how rewarding a reward is. This value signal can then be held in working memory where it can be used by lateral prefrontal cortex to plan and organize behavior toward obtaining the outcome, and by medial prefrontal cortex to evaluate the overall action in terms of its success and the effort that was required. Thus, acting together, these prefrontal areas can ensure that our behavior is most efficiently directed towards satisfying our needs.

Orbitofrontal cortex and its contribution to decision-making. Publishing Authors By Initials

JD Wallis,

For similar psychological phenomena and processes: mental processes: learning: reinforcement (psychology): reward research abstracts see: psychological phenomena and processes: mental processes: learning: reinforcement (psychology): reward research

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Orbitofrontal cortex and its contribution to decision-making. Journal Published:

PUBLICATION TYPE: Review

Journal: Annual review of neuroscience

VOLUME: 30

Page Numbers: 31-56

Journal Abbreviation: Annu. Rev. Neurosci.

ISSN: 0147-006X

DAY: 3

MONTH: 12

YEAR: 2007

Orbitofrontal cortex and its contribution to decision-making. Information

Number of References: 113

LANGUAGE: eng

NlmUniqueID: 7804039

Orbitofrontal cortex and its contribution to decision-making. Keywords Mesh Terms:

KEYWORDS: Reward

MESH TERMS: physiology

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Grant and Affiliation Information for Orbitofrontal cortex and its contribution to decision-making.

AFFILIATION: Helen Wills Neuroscience Institute and the Department of Psychology, University of California, Berkeley, California 94720-3190, USA. wallis@berkeley.edu

Country: United States

AGENCY: United States NIDA

GRANT: R01-DA019028

ACRONYM: DA

MEDLINETA: Annu Rev Neurosci

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