Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner.

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Abstract Text:

Yuri Kawasaki,Keiichi Kawagoe,Chun-jen Chen,Kenta Teruya,Yuji Sakasegawa,Katsumi Doh-ura,Yuri Kawasaki,Keiichi Kawagoe,Chun-jen Chen,Kenta Teruya,Yuji Sakasegawa,Katsumi Doh-ura,

The establishment of effective therapeutic interventions for prion diseases is necessary. We report on a newly developed amyloidophilic compound that displays therapeutic efficacy when administered orally. This compound inhibited abnormal prion protein formation in prion-infected neuroblastoma cells in a prion strain-dependent manner: effectively for RML prion and marginally for 22L prion and Fukuoka-1 prion. When the highest dose (0.2% [wt/wt] in feed) was given orally to cerebrally RML prion-inoculated mice from inoculation until the terminal stage of disease, it extended the incubation periods by 2.3 times compared to the control. The compound exerted therapeutic efficacy in a prion strain-dependent manner such as that observed in the cell culture study: most effective for RML prion, less effective for 22L prion or Fukuoka-1 prion, and marginally effective for 263K prion. Its effectiveness depended on an earlier start of administration. The glycoform pattern of the abnormal prion protein in the treated mice was modified and showed predominance of the diglycosylated form, which resembled that of 263K prion, suggesting that diglycosylated forms of abnormal prion protein might be least sensitive or resistant to the compound. The mechanism of the prion strain-dependent effectiveness needs to be elucidated and managed. Nevertheless, the identification of an orally available amyloidophilic chemical encourages the pursuit of chemotherapy for prion diseases.

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Publishing Authors By Initials

Y Kawasaki,K Kawagoe,CJ Chen,K Teruya,Y Sakasegawa,K Doh-ura,Y Kawasaki,K Kawagoe,CJ Chen,K Teruya,Y Sakasegawa,K Doh-ura,

For similar proteins: prions research abstracts see: proteins: prions research

PUBMED ID PMID:

MEDLINE DATE:

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 12889-98

Journal Abbreviation: J. Virol.

ISSN: 1098-5514

DAY: 19

MONTH: 09

YEAR: 2007

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Keywords Mesh Terms:

KEYWORDS: Prions

MESH TERMS: drug effects

Chemical & Substance for Abstract: Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Information

Substance Name: Prions

Registry Number: 0

Grant and Affiliation Information for Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner.

AFFILIATION: Department of Prion Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner Related Publications

• Brain stem lesions in sporadic Creutzfeldt-Jakob disease: a histopathological and immunohistochemical study.
• Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner.