Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review.

Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Research Abstract Details 

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Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Abstract Text:

Claudia Steurer-Stey,Leonie Lagler,Daniel A Straub,Johann Steurer,Lucas M Bachmann,

BACKGROUND: Recurrent acute respiratory tract infections (ARTI) are a common problem in childhood. Some evidence suggests a benefit regarding the prevention of ARTI in children treated with the immunomodulator OM-85 BV (Bronchovaxom). METHODS: We summarised the evidence on the effectiveness of the immunomodulator OM-85 BV in the prevention of ARTI in children. We searched randomised comparisons of oral purified bacterial extracts against inactive controls in children with respiratory tract diseases in nine electronic databases and reference lists of included studies. We extracted salient features of each study, calculated relative risks (RR) or weighted mean differences (WMD) and performed meta-analyses using random-effects models. RESULTS: Thirteen studies (2,721 patients) of low to moderate quality tested OM-85 BV. Patients and outcomes differed substantially, which impeded pooling results of more than two trials. Two studies (240 patients) reporting on the number of patients with less than three infections over 6 month of follow-up in children not in day care showed a trend for benefit RR 0.82 (95% CI, 0.65-1.02). One out of two studies examining the number of children not in day care without infections over 4-6 month reported a significant RR of 0.42 (95% CI, 0.21-0.82) whereas the smaller, second study did not [RR 0.92 (95% CI, 0.58-1.46)]. Two studies reporting the number of antibiotic courses indicated a benefit for the intervention arm [WMD 2.0 (95% CI, 1.7-2.3)]. Two out of the three studies showed a reduction of length of episodes of 4-6 days whereas a third study showed no difference between the two groups. CONCLUSION: Evidence in favour of OM-85 BV in the prevention of ARTI in children is weak. There is a trend for fewer and shorter infections and a reduction of antibiotic use.

Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Publishing Authors By Initials

C Steurer-Stey,L Lagler,DA Straub,J Steurer,LM Bachmann,

For similar bacterial infections and mycoses: infection: respiratory tract infections research abstracts see: bacterial infections and mycoses: infection: respiratory tract infections research

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Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Journal Published:

PUBLICATION TYPE: Review

Journal: European journal of pediatrics

VOLUME: 166

Page Numbers: 365-76

Journal Abbreviation: Eur. J. Pediatr.

ISSN: 0340-6199

DAY: 18

MONTH: 11

YEAR: 2006

Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Information

Number of References: 23

LANGUAGE: eng

NlmUniqueID: 7603873

Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Keywords Mesh Terms:

KEYWORDS: Respiratory Tract Infections

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Information

Substance Name: bacterial lysate

Registry Number: 0

Grant and Affiliation Information for Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review.

AFFILIATION: Medical Policlinic, Department of Internal Medicine, University Hospital, Raemistrasse 100, CH-8091, Zurich, Switzerland. claudia.stey@usz.ch

Country: Germany

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MEDLINETA: Eur J Pediatr

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