Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice.

Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Research Abstract Details 

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Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Abstract Text:

Naghma Khan,Farrukh Afaq,Mee-Hyang Kweon,Kyungmann Kim,Hasan Mukhtar,

To develop novel mechanism-based preventive approaches for lung cancer, we examined the effect of oral consumption of a human achievable dose of pomegranate fruit extract (PFE) on growth, progression, angiogenesis, and signaling pathways in two mouse lung tumor protocols. Benzo(a)pyrene [B(a)P] and N-nitroso-tris-chloroethylurea (NTCU) were used to induce lung tumors, and PFE was given in drinking water to A/J mice. Lung tumor yield was examined on the 84th day and 140 days after B(a)P dosing and 240 days after NTCU treatment. Mice treated with PFE and exposed to B(a)P and NTCU had statistically significant lower lung tumor multiplicities than mice treated with carcinogens only. Tumor reduction was 53.9% and 61.6% in the B(a)P + PFE group at 84 and 140 days, respectively, compared with the B(a)P group. The NTCU + PFE group had 65.9% tumor reduction compared with the NTCU group at 240 days. Immunoblot analysis and immunohistochemistry were used to determine effect on cell survival pathways and markers of cellular proliferation and angiogenesis. PFE treatment caused inhibition of (a) activation of nuclear factor-kappaB and IkappaBalpha kinase, (b) degradation and phosphorylation of IkappaBalpha, (c) phosphorylation of mitogen-activated protein kinases (extracellular signal-regulated kinase 1/2, c-Jun NH(2)-terminal kinase 1/2, and p38), (d) phosphatidylinositol 3-kinase (p85 and p110), (e) phosphorylation of Akt at Thr(308), (f) activation of mammalian target of rapamycin signaling, (g) phosphorylation of c-met, and (h) markers of cell proliferation (Ki-67 and proliferating cell nuclear antigen) and angiogenesis (inducible nitric oxide synthase, CD31, and vascular endothelial growth factor) in lungs of B(a)P- and NTCU-treated mice. Thus, our data show that PFE significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer.

Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Publishing Authors By Initials

N Khan,F Afaq,MH Kweon,K Kim,H Mukhtar,

For similar organic chemicals: urea research abstracts see: organic chemicals: urea research

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Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 67

Page Numbers: 3475-82

Journal Abbreviation:

ISSN: 0008-5472

DAY: 27

MONTH: 03

YEAR: 2007

Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Keywords Mesh Terms:

KEYWORDS: Urea

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Information

Substance Name: Proto-Oncogene Proteins c-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice.

AFFILIATION: Department of Dermatology and Biostatistics and Medical Informatics, University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA78809

ACRONYM: CA

MEDLINETA: Cancer Res

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