Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets.

Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets. Research Abstract Details 

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Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets. Abstract Text:

Atsushi Yoshida,Xue Deng,Takashi Sasano,Haruhiko Takada,Shunji Sugawara,Yasuo Endo,

Microbial infection is thought to modulate allergic disorders, and we previously demonstrated that not only mast cells (which release histamine), but also platelets are involved in the anaphylaxis induced in mice sensitised to ovalbumin (OVA). Here, we examined the effects of a lipopolysaccharide (LPS) from the oral bacterium Prevotella intermedia (Pi) on OVA-induced anaphylaxis. Upon intraperitoneal co-injection of Pi-LPS plus OVA into BALB/c mice, the Pi-LPS displayed a potent adjuvant effect comparable to that of alum (a standard adjuvant) in terms of its abilities to induce both anaphylactic shock and histamine-release following an antigen (OVA)-challenge. Moreover, an injection of Pi-LPS given to OVA+alum-sensitised mice shortly before an OVA-challenge augmented the shock-response. This LPS-pretreatment did not affect histamine-release, but did augment pulmonary platelet accumulation. Histamine was not by itself causal for shock-induction in sensitised mice. These results suggest that oral bacteria and/or their constituents (such as LPS) may help to sensitise the host to an antigen or exacerbate the host's allergic reactions ("aggravation effect"), probably by enhancing the platelet response to the antigen OVA.

Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets. Publishing Authors By Initials

A Yoshida,X Deng,T Sasano,H Takada,S Sugawara,Y Endo,

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Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of oral biology

VOLUME: 52

Page Numbers: 990-4

Journal Abbreviation: Arch. Oral Biol.

ISSN: 0003-9969

DAY: 7

MONTH: 06

YEAR: 2007

Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets. Information

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LANGUAGE: eng

NlmUniqueID: 116711

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Grant and Affiliation Information for Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets.

AFFILIATION: Department of Molecular Regulation, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Country: England

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MEDLINETA: Arch Oral Biol

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