Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.

Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Research Abstract Details 

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Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Abstract Text:

Multifunctional transcription factor TFII-I has two spliced isoforms (Delta and beta) in murine fibroblasts. Here we show that these isoforms have distinct subcellular localization and mutually exclusive transcription functions in the context of growth factor signaling. In the absence of signaling, TFII-Ibeta is nuclear and recruited to the c-fos promoter in vivo. But upon growth factor stimulation, the promoter recruitment is abolished and it is exported out of the nucleus. Moreover, isoform-specific silencing of TFII-Ibeta results in transcriptional activation of the c-fos gene. In contrast, TFII-IDelta is largely cytoplasmic in the resting state but translocates to the nucleus upon growth factor signaling, undergoes signal-induced recruitment to the same site on the c-fos promoter, and activates the gene. Importantly, activated TFII-IDelta interacts with Erk1/2 (MAPK) kinase in the cell cytoplasm and imports the Erk1/2 to the nucleus, thereby transducing growth factor signaling. Our results identify a unique growth factor signaling pathway controlled by opposing activities of two TFII-I spliced isoforms.

Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Publishing Authors By Initials

For similar proteins: dna-binding proteins: transcription factors, general: transcription factors, tfii research abstracts see: proteins: dna-binding proteins: transcription factors, general: transcription factors, tfii research

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Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular cell

VOLUME: 24

Page Numbers: 301-8

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 20

MONTH: Oct

YEAR: 2006

Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Keywords Mesh Terms:

KEYWORDS: Transcription Factors, TFII

MESH TERMS: chemistry

Chemical & Substance for Abstract: Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Information

Substance Name: Transcription Factors, TFII

Registry Number: 0

Grant and Affiliation Information for Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.

AFFILIATION: Program in Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R37-GM34277

ACRONYM: GM

MEDLINETA: Mol Cell

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