Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex.

Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex. Research Abstract Details 

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Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex. Abstract Text:

Seigo Suzuki,Hongyi Zhou,John F Neumaier,Tony A Pham,

Most excitatory inputs onto pyramidal neurons are made on dendritic spines. The geometry of dendritic spines modulates synaptic function; yet we know little regarding the molecular signals that regulate spine geometry. Here we report that neurons coordinately regulate the geometry of spines to compensate for variability in spine number, by a process requiring the transcription factor CREB and the kinase MKK1. We find that CREB function is induced, whereas MKK1 is inhibited, by activity blockade. To obtain evidence that CREB and MKK1 regulate dendritic spine geometry in vivo, we coexpressed green fluorescent protein and dominant negative CREB or MKK1 in pyramidal neurons of the intact rat visual cortex. Spines on apical dendrites of layer 3 neurons were then characterized by confocal microscopy. We find that CREB and MKK1 regulate spine geometry in opposite ways. MKK1 is required to reduce spine head size when spine density is high, whereas CREB is required to enlarge spines when spine density is low. Our data suggest that CREB and MKK1 might function as complementary negative feedback mechanisms to maintain synaptic drive within bounds.

Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex. Publishing Authors By Initials

S Suzuki,H Zhou,JF Neumaier,TA Pham,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research

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Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of comparative neurology

VOLUME: 503

Page Numbers: 605-17

Journal Abbreviation: J. Comp. Neurol.

ISSN: 0021-9967

DAY: 10

MONTH: Aug

YEAR: 2007

Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 406041

Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex. Keywords Mesh Terms:

KEYWORDS: Visual Cortex

MESH TERMS: cytology

Chemical & Substance for Abstract: Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex. Information

Substance Name: MAP Kinase Kinase 1

Registry Number: EC 2.7.1.-

Grant and Affiliation Information for Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex.

AFFILIATION: Department of Molecular and Cellular Biology, Psychiatry and Behavioral Sciences, and Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.

Country: United States

AGENCY: United States NEI

GRANT: R01 EY014238

ACRONYM: EY

MEDLINETA: J Comp Neurol

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