Opioid receptors regulate retrieval of infant fear memories: effects of naloxone on infantile amnesia.

Opioid receptors regulate retrieval of infant fear memories: effects of naloxone on infantile amnesia. Research Abstract Details 

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Opioid receptors regulate retrieval of infant fear memories: effects of naloxone on infantile amnesia. Abstract Text:

Marianne Weber,Gavan P McNally,Rick Richardson,

The authors examined the role of the endogenous opioid system in infantile amnesia for contextual fear conditioning. Rats that were 18 days of age received an aversive footshock in a novel context. Rats displayed conditioned fear when tested 1 min after training but not 24 hr after training. Systemic injection of the opioid receptor antagonist naloxone prior to test, but not immediately after training, alleviated infantile amnesia. Naloxone also alleviated infantile amnesia when injected prior to test 7 days after training. These effects of naloxone were due to actions on central rather than peripheral opioid receptors and were not due to any tendency of the drug to produce fear or freezing. These results show that central opioid receptors regulate retrieval of fear memories in infant rats. ((c) 2006 APA, all rights reserved).

Opioid receptors regulate retrieval of infant fear memories: effects of naloxone on infantile amnesia. Publishing Authors By Initials

M Weber,GP McNally,R Richardson,

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Opioid receptors regulate retrieval of infant fear memories: effects of naloxone on infantile amnesia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Behavioral neuroscience

VOLUME: 120

Page Numbers: 702-9

Journal Abbreviation: Behav. Neurosci.

ISSN: 0735-7044

DAY: 13

MONTH: Jun

YEAR: 2006

Opioid receptors regulate retrieval of infant fear memories: effects of naloxone on infantile amnesia. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Opioid receptors regulate retrieval of infant fear memories: effects of naloxone on infantile amnesia.

AFFILIATION: School of Psychology, University of New South Wales, Sydney, Australia.

Country: United States

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MEDLINETA: Behav Neurosci

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