Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy.

Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. Research Abstract Details 

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Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. Abstract Text:

The effectiveness of an antihistamine, chlorpheniramine, in suppressing chloroquine-related pruritus has been investigated in 38 patients, employing two modes of therapy. In the first treatment mode, chloroquine and chlorpheniramine were given concomitantly to the patient, and in the second treatment mode, chlorpheniramine was given 3 h after chloroquine ingestion. The extent of suppression of the pruritus with the first treatment mode was 40% but with the second mode it was 70%. The onset of itching was always delayed usually by 6-10 h. Bringing the time of antihistamine therapy closer to the onset for the reaction therefore, increased the extent to which pruritus was suppressed.

Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. Publishing Authors By Initials

For similar skin and connective tissue diseases: skin diseases: pruritus research abstracts see: skin and connective tissue diseases: skin diseases: pruritus research

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Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 16

Page Numbers: 463-5

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Dec

YEAR: 1991

Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. Information

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LANGUAGE: eng

NlmUniqueID: 8704308

Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. Keywords Mesh Terms:

KEYWORDS: Pruritus

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. Information

Substance Name: Chloroquine

Registry Number: 54-05-7

Grant and Affiliation Information for Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy.

AFFILIATION: Department of Pharmaceutics, College of Medical Sciences, University of Benin, Nigeria.

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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