One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study.

One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study. Research Abstract Details 

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One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study. Abstract Text:

Yoko Matsuda,Masanao Yokohira,Satoshi Suzuki,Kyoko Hosokawa,Keiko Yamakawa,Yu Zeng,Fumiko Ninomiya,Kousuke Saoo,Toshiya Kuno,Katsumi Imaida,

This study was conducted to evaluate the chronic toxicity of Aloe arborescens Miller var. natalensis Berger (ALOE) in the diet at doses of 4.0%, 0.8% or 0.16% to groups of male and female Wistar Hannover rats. No deaths occurred at any dose level throughout the treatment period. Both sexes receiving 4.0% showed diarrhea, with a reduced body weight gain. Increase of WBCs in the male 4.0% group, decrease of Hb in the female 4.0% and 0.8% groups, decrease of IP in the male 4.0% and 0.8% groups and female 4.0% group, and decrease of Ca and ALT in the female 4.0% group were observed. Relative kidney weight showed increase in the female 4.0% group and relative heart and brain weights were decreased in the female 4.0% and 0.8% groups. Histopathologically, both sexes receiving 4.0% showed severe sinus dilatation of ileocecal lymph nodes, and yellowish pigmentation of ileocecal lymph nodes and renal tubules. In conclusion, the no observed adverse effect level (NOAEL) for ALOE was the 0.16% in diet, which is equivalent to 87.7 and 109.7mg/kg/day in males and females, respectively.

One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study. Publishing Authors By Initials

Y Matsuda,M Yokohira,S Suzuki,K Hosokawa,K Yamakawa,Y Zeng,F Ninomiya,K Saoo,T Kuno,K Imaida,

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One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Food and chemical toxicology : an international jo

VOLUME: 46

Page Numbers: 733-9

Journal Abbreviation: Food Chem. Toxicol.

ISSN: 0278-6915

DAY: 1

MONTH: 10

YEAR: 2007

One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study. Information

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LANGUAGE: eng

NlmUniqueID: 8207483

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AFFILIATION: Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Country: England

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MEDLINETA: Food Chem Toxicol

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