Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Research Abstract Details 

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Abstract Text:

Brooke Ancrile,Kian-Huat Lim,Christopher M Counter,

Ras is mutated to remain in the active oncogenic state in many cancers. As Ras has proven difficult to target therapeutically, we searched for secreted, druggable proteins induced by Ras that are required for tumorigenesis. We found that Ras induces the secretion of cytokine IL6 in different cell types, and that knockdown of IL6, genetic ablation of the IL6 gene, or treatment with a neutralizing IL6 antibody retard Ras-driven tumorigenesis. IL6 appears to act in a paracrine fashion to promote angiogenesis and tumor growth. Inhibiting IL6 may therefore have therapeutic utility for treatment of cancers characterized by oncogenic Ras mutations.

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Publishing Authors By Initials

B Ancrile,KH Lim,CM Counter,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes & development

VOLUME: 21

Page Numbers: 1714-9

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 15

MONTH: Jul

YEAR: 2007

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Information

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LANGUAGE: eng

NlmUniqueID: 8711660

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: genetics

Chemical & Substance for Abstract: Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

AFFILIATION: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA94184

ACRONYM: CA

MEDLINETA: Genes Dev

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