Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen.

Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen. Research Abstract Details 

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Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen. Abstract Text:

W J Fokkens,R Jogi,S Reinartz,I Sidorenko,B Sitkauskiene,C van Oene,M A Faris,A Ellsworth,M F Caldwell,W J Fokkens,R Jogi,S Reinartz,I Sidorenko,B Sitkauskiene,C van Oene,M A Faris,A Ellsworth,M F Caldwell,

BACKGROUND: Fluticasone furoate is a new enhanced-affinity glucocorticoid with a unique combination of pharmacodynamic and physicochemical properties suitable for topical activity. METHODS: In this multicentre, randomized, double-blind, placebo-controlled, parallel-group study, patients [adults and adolescents >or=12 years of age with seasonal allergic rhinitis (SAR)] received once-daily (od) treatment for 2 weeks with either fluticasone furoate nasal spray 110 microg (n = 141) or placebo nasal spray (n = 144) administered in a unique, side-actuated device. Efficacy measures included total nasal symptom score (TNSS) and total ocular symptom score (TOSS). Patients also reported their overall response to therapy and rated their quality of life using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). RESULTS: Fluticasone furoate significantly improved the mean change from baseline in daily reflective TNSS compared with placebo (treatment difference of -1.757; P < 0.001). Fluticasone furoate was also significantly more effective in improving the morning predose instantaneous TNSS (treatment difference of -1.898; P < 0.001) and daily reflective TOSS (treatment difference of -0.741; P = 0.001). A significant treatment effect was observed as early as day 1. Compared with placebo-treated patients, fluticasone furoate-treated patients showed significantly greater improvements in overall evaluation of response to therapy (P < 0.001), as well as in overall RQLQ score (P < 0.001). Fluticasone furoate was well tolerated. CONCLUSION: Fluticasone furoate nasal spray 110 mug od was effective in improving the nasal symptoms of SAR. It also produced significant improvements in ocular symptoms.

Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen. Publishing Authors By Initials

WJ Fokkens,R Jogi,S Reinartz,I Sidorenko,B Sitkauskiene,C van Oene,MA Faris,A Ellsworth,MF Caldwell,WJ Fokkens,R Jogi,S Reinartz,I Sidorenko,B Sitkauskiene,C van Oene,MA Faris,A Ellsworth,MF Caldwell,

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Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Allergy

VOLUME: 62

Page Numbers: 1078-84

Journal Abbreviation: Allergy

ISSN: 0105-4538

DAY: 9

MONTH: Sep

YEAR: 2007

Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen. Information

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LANGUAGE: eng

NlmUniqueID: 7804028

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AFFILIATION: Academisch Medisch Centrum, Divisie Neurozintuigspecialismen, Polikliniek KNO, Amsterdam, The Netherlands.

Country: Denmark

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MEDLINETA: Allergy

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