On use of the multistage dose-response model for assessing laboratory animal carcinogenicity.

On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Research Abstract Details 

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On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Abstract Text:

Daniela K Nitcheva,Walter W Piegorsch,R Webster West,

We explore how well a statistical multistage model describes dose-response patterns in laboratory animal carcinogenicity experiments from a large database of quantal response data. The data are collected from the US EPA's publicly available IRIS data warehouse and examined statistically to determine how often higher-order values in the multistage predictor yield significant improvements in explanatory power over lower-order values. Our results suggest that the addition of a second-order parameter to the model only improves the fit about 20% of the time, while adding even higher-order terms apparently does not contribute to the fit at all, at least with the study designs we captured in the IRIS database. Also included is an examination of statistical tests for assessing significance of higher-order terms in a multistage dose-response model. It is noted that bootstrap testing methodology appears to offer greater stability for performing the hypothesis tests than a more-common, but possibly unstable, "Wald" test.

On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Publishing Authors By Initials

DK Nitcheva,WW Piegorsch,RW West,

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On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Regulatory toxicology and pharmacology : RTP

VOLUME: 48

Page Numbers: 135-47

Journal Abbreviation: Regul. Toxicol. Pharmacol.

ISSN: 0273-2300

DAY: 25

MONTH: 03

YEAR: 2007

On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Information

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LANGUAGE: eng

NlmUniqueID: 8214983

On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Keywords Mesh Terms:

KEYWORDS: United States Environmental Protection A

MESH TERMS: methods

Chemical & Substance for Abstract: On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Information

Substance Name: Carcinogens

Registry Number: 0

Grant and Affiliation Information for On use of the multistage dose-response model for assessing laboratory animal carcinogenicity.

AFFILIATION: Department of Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA. nitcheva@gwm.sc.edu

Country: United States

AGENCY: United States NCI

GRANT: R01-CA76031

ACRONYM: CA

MEDLINETA: Regul Toxicol Pharmacol

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