[On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients]

[On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients] Research Abstract Details 

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[On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients] Abstract Text:

,I I Dement'eva,V G Gladysheva,M A Charnaia,Iu A Morozov,

Recombinant activated factor VII was used in a dose of 30 to 140 mcgr/kg in 35 cardiosurgical patients during intra- and postoperative periods complicated by massive uncontrolled (5 to 25 ml/min) bleeding of non-surgical origin. Basing on the analysis of changes in the hemostasis system parameters, the mechanism of action of the preparation may be presented as follows: recombinant fVIIa forms a complex with TF at the site of lesion; the formation of TF-fVIIa complex leads to the appearance of small amount of synthesized thrombin on the membrane of TF-containing cells, which, in turn, activates thrombocytes at the site of lesion; thrombocytes excrete phosphatidylserine, which serves as a matrix for further thrombin formation. FXIII is expressed from a granules ofthrombocytes and gets activated. FXIII binds with a specific receptor on platelets' membrane. It remains active as enzyme and participates in the formation of a firm fibrin plug at the site of lesion. Besides, substances with pro- and antifibrinolytic activity, antiheparin factor 4 and fibronectin are released from alpha granules. Factors IXa, VIIIa, and Va effectively "attach" to the surface of activated thrombocytes, and the forming of IXa-VIIIa complex leads to further activation of factor X, which, together with factor 3 expression, facilitates further local thrombin generation.

[On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients] Publishing Authors By Initials

,II Dement'eva,VG Gladysheva,MA Charnaia,IuA Morozov,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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[On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vestnik Rossi?sko? akademii meditsinskikh nauk / R

VOLUME:

Page Numbers: 21-5

Journal Abbreviation: Vestn. Akad. Med. Nauk SSSR

ISSN: 0869-6047

DAY: 20

MONTH: 12

YEAR: 2006

[On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients] Information

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LANGUAGE: rus

NlmUniqueID: 9215641

[On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients] Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: metabolism

Chemical & Substance for Abstract: [On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients] Information

Substance Name: Factor VIIa

Registry Number: EC 3.4.21.21

Grant and Affiliation Information for [On the mechanism of action of recombinant activated factor VII in massive non-hemophylic bleeding in cardiosurgical patients]

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Country: Russia (Federation)

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MEDLINETA: Vestn Ross Akad Med Nauk

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