On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements.

On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements. Research Abstract Details 

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On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements. Abstract Text:

R S Figliola,T J Mueller,

An experimental investigation was conducted to determine the magnitude of shear stresses and areas of stasis of several types of prosthetic occluder heart valves. These experiments were performed in a steady-flow test loop using an axisymmetric aortic-shaped test chamber and an aqueous-glycerine solution. The flow loop produced a low-turbulence intensity and uniform mean velocity profile upstream of the test chamber. Tests were performed on a Kay-Shiley disk, a Bjork-Shiley tilting disk and Starr-Edwards Models 1260 and 2320 ball prostheses at Reynolds numbers between 2000 and 6200. Momentum transfer and turbulence data were obtained both around and distal to the valve occluders using laser Doppler and hot-film anemometry. The region directly surrounding the valve occluders contained the largest stresses measured. Aortic wall shear measurements revealed magnitudes potentially damaging to the vessel lining. Regions of slowly moving separated flow found to exist in these occluder valve flow fields correlated with clinical findings of thrombus formation.

On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements. Publishing Authors By Initials

RS Figliola,TJ Mueller,

For similar cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis research abstracts see: cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis research

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On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomechanical engineering

VOLUME: 103

Page Numbers: 83-90

Journal Abbreviation:

ISSN: 0148-0731

DAY: 3

MONTH: May

YEAR: 1981

On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements. Information

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LANGUAGE: eng

NlmUniqueID: 7909584

On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements. Keywords Mesh Terms:

KEYWORDS: Thrombosis

MESH TERMS: etiology

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Grant and Affiliation Information for On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: R21 HL083975-01A1

ACRONYM: HL

MEDLINETA: J Biomech Eng

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