On the equivalence of case-crossover and time series methods in environmental epidemiology.

On the equivalence of case-crossover and time series methods in environmental epidemiology. Research Abstract Details 

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On the equivalence of case-crossover and time series methods in environmental epidemiology. Abstract Text:

Yun Lu,Scott L Zeger,

The case-crossover design was introduced in epidemiology 15 years ago as a method for studying the effects of a risk factor on a health event using only cases. The idea is to compare a case's exposure immediately prior to or during the case-defining event with that same person's exposure at otherwise similar "reference" times. An alternative approach to the analysis of daily exposure and case-only data is time series analysis. Here, log-linear regression models express the expected total number of events on each day as a function of the exposure level and potential confounding variables. In time series analyses of air pollution, smooth functions of time and weather are the main confounders. Time series and case-crossover methods are often viewed as competing methods. In this paper, we show that case-crossover using conditional logistic regression is a special case of time series analysis when there is a common exposure such as in air pollution studies. This equivalence provides computational convenience for case-crossover analyses and a better understanding of time series models. Time series log-linear regression accounts for overdispersion of the Poisson variance, while case-crossover analyses typically do not. This equivalence also permits model checking for case-crossover data using standard log-linear model diagnostics.

On the equivalence of case-crossover and time series methods in environmental epidemiology. Publishing Authors By Initials

Y Lu,SL Zeger,

For similar investigative techniques: epidemiologic methods: statistics as topic: models, statistical: logistic models research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: models, statistical: logistic models research

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On the equivalence of case-crossover and time series methods in environmental epidemiology. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biostatistics (Oxford, England)

VOLUME: 8

Page Numbers: 337-44

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ISSN: 1465-4644

DAY: 29

MONTH: 06

YEAR: 2006

On the equivalence of case-crossover and time series methods in environmental epidemiology. Information

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LANGUAGE: eng

NlmUniqueID: 100897327

On the equivalence of case-crossover and time series methods in environmental epidemiology. Keywords Mesh Terms:

KEYWORDS: Logistic Models

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Grant and Affiliation Information for On the equivalence of case-crossover and time series methods in environmental epidemiology.

AFFILIATION: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205-2179, USA. ylu@jhsph.edu

Country: England

AGENCY: United States NIEHS

GRANT: P30 ES03819

ACRONYM: ES

MEDLINETA: Biostatistics

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