On the dynamics of electrically-coupled neurons with inhibitory synapses.

On the dynamics of electrically-coupled neurons with inhibitory synapses. Research Abstract Details 

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On the dynamics of electrically-coupled neurons with inhibitory synapses. Abstract Text:

Juan Gao,Philip Holmes,

We study the dynamics and bifurcations of noise-free neurons coupled by gap junctions and inhibitory synapses, using both delayed delta functions and alpha functions to model the latter. We focus on the case of two cells, as in the studies of Chow and Kopell (2000) and Lewis and Rinzel (2003), but also show that stable asynchronous splay states exist for globally coupled networks of N cells dominated by subthreshold electrical coupling. Our results agree with those of Lewis and Rinzel (2003) in the weak coupling range, but our Poincaré map analysis yields more information about global behavior and domains of attraction, and we show that the explicit discontinuous maps derived using delayed delta functions compare well with the continuous history-dependent, implicitly-defined maps derived from alpha functions. We find that increased bias currents, super-threshold electrical coupling and synaptic delays promote synchrony, while sub-threshold electrical coupling and fast synapses promote asynchrony. We compare our analytical results with simulations of an ionic current model of spiking cells, and briefly discuss implications for stimulus response modes of locus coeruleus and for central pattern generators.

On the dynamics of electrically-coupled neurons with inhibitory synapses. Publishing Authors By Initials

J Gao,P Holmes,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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On the dynamics of electrically-coupled neurons with inhibitory synapses. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of computational neuroscience

VOLUME: 22

Page Numbers: 39-61

Journal Abbreviation:

ISSN: 0929-5313

DAY: 19

MONTH: 09

YEAR: 2006

On the dynamics of electrically-coupled neurons with inhibitory synapses. Information

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LANGUAGE: eng

NlmUniqueID: 9439510

On the dynamics of electrically-coupled neurons with inhibitory synapses. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: On the dynamics of electrically-coupled neurons with inhibitory synapses. Information

Substance Name: Ion Channels

Registry Number: 0

Grant and Affiliation Information for On the dynamics of electrically-coupled neurons with inhibitory synapses.

AFFILIATION: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA. jgao@princeton.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH62196

ACRONYM: MH

MEDLINETA: J Comput Neurosci

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