On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia.

On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia. Research Abstract Details 

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On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia. Abstract Text:

Schizophrenia patients have been shown to have a defective sensorimotor gating process as indexed by impaired prepulse inhibition of the startle eyeblink reflex. Moreover, we have previously reported that schizophrenia patients have dysfunctional attentional modulation of prepulse inhibition. The present experiment combined our previous sample of 14 schizophrenia outpatients and 12 demographically matched control subjects with a new sample of 10 outpatients and 6 control subjects. All participants performed a tone-length judgement task that involved attending to one pitch of tone (the attended prepulse) and ignoring another pitch of tone (the ignored prepulse). During this task the acoustic startle eyeblink reflex was electromyographically recorded from the orbicularis oculi muscle. The results replicated the finding of impaired attentional modulation of prepulse inhibition in the new sample of schizophrenia outpatients compared to demographically matched control subjects. Specifically, the new control group exhibited greater startle modification during the attended prepulse, whereas the new patient group failed to show this differential effect. In addition, impaired prepulse inhibition following the attended prepulse was significantly correlated with heightened delusions, conceptual disorganization, and suspiciousness as measured with the expanded Brief Psychiatric Rating Scale. These correlations were significant with prepulse inhibition to the attended prepulse but not with prepulse inhibition to the ignored prepulse. Impaired prepulse inhibition was not correlated with negative symptoms. All in all, the results support the hypothesis that impaired attentional modulation of startle prepulse inhibition reflects basic neurocognitive processes related to thought disorder in schizophrenia.

On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia. Publishing Authors By Initials

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Psychiatry research

VOLUME: 96

Page Numbers: 187-97

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 20

MONTH: Nov

YEAR: 2000

On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: physiopathology

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Grant and Affiliation Information for On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia.

AFFILIATION: Department of Psychology, SGM 501, University of Southern California, Los Angeles, CA 90089-1061, USA. mdawson@rcf.usc.edu

Country: IRELAND

AGENCY: United States NIMH

GRANT: MH46433

ACRONYM: MH

MEDLINETA: Psychiatry Res

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