On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice.

On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Research Abstract Details 

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On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Abstract Text:

David Fardo,Juan C ,Benjamin A Raby,Scott T Weiss,Christoph Lange,

In family-based association studies, quantitative traits are thought to provide higher statistical power than dichotomous traits. Consequently, it is standard practice to collect quantitative traits and to analyze them as such. However, in many situations, continuous measurements are more difficult to obtain and/or need to be adjusted for other factors/confounding variables which also have to be measured. In such scenarios, it can be advantageous to record and analyze a "simplified/dichotomized" version of the original trait. Under fairly general circumstances, we derive here rules for the dichotomization of quantitative traits that maintain power levels that are comparable to the analysis of the original quantitative trait. Using simulation studies, we show that the proposed rules are robust against phenotypic misclassification, making them an ideal tool for inexpensive phenotyping in large-scale studies. The guidelines are illustrated by an application to an asthma study.

On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Publishing Authors By Initials

D Fardo,JC ,BA Raby,ST Weiss,C Lange,

For similar genetic phenomena: inheritance patterns: quantitative trait, heritable research abstracts see: genetic phenomena: inheritance patterns: quantitative trait, heritable research

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On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genetic epidemiology

VOLUME: 31

Page Numbers: 376-82

Journal Abbreviation: Genet. Epidemiol.

ISSN: 0741-0395

DAY: 3

MONTH: Jul

YEAR: 2007

On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Information

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LANGUAGE: eng

NlmUniqueID: 8411723

On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Keywords Mesh Terms:

KEYWORDS: Quantitative Trait, Heritable

MESH TERMS: physiopathology

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Grant and Affiliation Information for On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice.

AFFILIATION: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. dfardo@hsph.farvard.edu

Country: United States

AGENCY: United States NIDDK

GRANT: T90 DK070078

ACRONYM: DK

MEDLINETA: Genet Epidemiol

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