Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles.

Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles. Research Abstract Details 

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Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles. Abstract Text:

David A Giljohann,Dwight S Seferos,Pinal C Patel,Jill E Millstone,Nathaniel L Rosi,Chad A Mirkin,David A Giljohann,Dwight S Seferos,Pinal C Patel,Jill E Millstone,Nathaniel L Rosi,Chad A Mirkin,

The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles. Publishing Authors By Initials

DA Giljohann,DS Seferos,PC Patel,JE Millstone,NL Rosi,CA Mirkin,DA Giljohann,DS Seferos,PC Patel,JE Millstone,NL Rosi,CA Mirkin,

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Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nano letters

VOLUME: 7

Page Numbers: 3818-21

Journal Abbreviation: Nano Lett.

ISSN: 1530-6984

DAY: 13

MONTH: 11

YEAR: 2007

Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles. Information

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LANGUAGE: eng

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AFFILIATION: Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113.

Country: United States

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MEDLINETA: Nano Lett

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