Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery.

Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Research Abstract Details 

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Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Abstract Text:

I A Khalil,K Kogure,S Futaki,S Hama,H Akita,M Ueno,H Kishida,M Kudoh,Y Mishina,K Kataoka,M Yamada,H Harashima,

This study describes a multifunctional envelope-type nano device (MEND) that mimics an envelope-type virus based on a novel packaging strategy. MEND particles contain a DNA core packaged into a lipid envelope modified with an octaarginine peptide. The peptide mediates internalization via macropinocytosis, which avoids lysosomal degradation. MEND-mediated transfection of a luciferase expression plasmid achieved comparable efficiency to adenovirus-mediated transfection, with lower associated cytotoxicity. Furthermore, topical application of MEND particles containing constitutively active bone morphogenetic protein (BMP) type IA receptor (caBmpr1a) gene had a significant impact on hair growth in vivo. These data demonstrate that MEND is a promising non-viral gene delivery system that may provide superior results to existing non-viral gene delivery technologies.

Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Publishing Authors By Initials

IA Khalil,K Kogure,S Futaki,S Hama,H Akita,M Ueno,H Kishida,M Kudoh,Y Mishina,K Kataoka,M Yamada,H Harashima,

For similar enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: galactosidases: beta-galactosidase research abstracts see: enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: galactosidases: beta-galactosidase research

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Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gene therapy

VOLUME: 14

Page Numbers: 682-9

Journal Abbreviation: Gene Ther.

ISSN: 0969-7128

DAY: 1

MONTH: 02

YEAR: 2007

Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9421525

Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Keywords Mesh Terms:

KEYWORDS: beta-Galactosidase

MESH TERMS: genetics

Chemical & Substance for Abstract: Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Information

Substance Name: beta-Galactosidase

Registry Number: EC 3.2.1.23

Grant and Affiliation Information for Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery.

AFFILIATION: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.

Country: England

AGENCY: United States NIEHS

GRANT: Z01 ES071003-08

ACRONYM: ES

MEDLINETA: Gene Ther

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