Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells.

Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells. Research Abstract Details 

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Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells. Abstract Text:

F Elling,

Mycotoxic porcine nephropathy was induced by p.o. administration of crystalline ochratoxin A for periods of 5 days, 3 months and 2 years. Enzyme activities of the renal tissue were studied histochemically. These were NADH-tetrazolium reductase, NADPH-tetrazolium reductase, lactate dehydrogenase, isocitrate dehydrogenase, succinate dehydrogenase, glucose-6-phosphate dehydrogenase, alpha-glycerophosphate dehydrogenase, unspecific acid phosphatase and unspecific alkaline phosphatase. The activity of NADH-tetrazolium reductase and succinate dehydrogenase was reduced in the proximal tubule of all nephrons after 5 days ochratoxin A exposure and remained reduced after 3 months and 2 years exposure. The effect of ochratoxin A on these enzymes would appear to cause the impairment of proximal tubular function and the morphological changes observed in the proximal tubule in ochratoxin A-induced mycotoxic porcine nephropathy. The localization of alterations in enzyme activity corresponds to the localization of ochratoxin A previously demonstrated in the kidney. The activities of NADPH-tetrazolium reductase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase and unspecific alkaline phosphatase were reduced focally corresponding to the areas with focal tubular atrophy and the degree of reduction was roughly parallel to the degree of atrophy.

Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells. Publishing Authors By Initials

F Elling,

For similar animal diseases: swine diseases research abstracts see: animal diseases: swine diseases research

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Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 87A

Page Numbers: 237-43

Journal Abbreviation:

ISSN: 0365-4184

DAY: 20

MONTH: Jul

YEAR: 1979

Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells. Information

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LANGUAGE: eng

NlmUniqueID: 7508468

Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells. Keywords Mesh Terms:

KEYWORDS: Swine Diseases

MESH TERMS: enzymology

Chemical & Substance for Abstract: Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells. Information

Substance Name: Acid Phosphatase

Registry Number: EC 3.1.3.2

Grant and Affiliation Information for Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Scand [A

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