Obsessive-compulsive disorder: boundary issues.

Obsessive-compulsive disorder: boundary issues. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Obsessive-compulsive disorder: boundary issues. Abstract Text:

Naomi A Fineberg,Sanjaya Saxena,Joseph Zohar,Kevin J Craig,

The boundaries between obsessive-compulsive disorder (OCD) and other neuropsychiatric disorders remain unresolved and may well differ from one disorder to another. Endophenotypes are heritable, quantitative traits hypothesized to more closely represent genetic risk for complex polygenic mental disorders than overt symptoms and behaviors. They may have a role in identifying how closely these disorders are associated with another and with other mental disorders with which they share major comorbidity. This review maps the nosological relationships of OCD to other neuropsychiatric disorders, using OCD as the prototype disorder and endophenotype markers, such as cognitive, imaging, and molecular data as well as results from demographic, comorbidity, family, and treatment studies. Despite high comorbidity rates, emerging evidence suggests substantial endophenotypic differences between OCD and anxiety disorders, depression, schizophrenia, and addictions, though comparative data is lacking and the picture is far from clear. On the other hand, strong relationships between OCD, Tourette syndrome, body dysmorphic disorder, hypochondriasis, grooming disorders, obsessive-compulsive personality disorder, and pediatric autoimmune neuropsychiatric disorders associated with streptococcus are likely. Studies designed to delineate the cause, consequences, and common factors are a challenging but essential goal for future research in this area.

Obsessive-compulsive disorder: boundary issues. Publishing Authors By Initials

NA Fineberg,S Saxena,J Zohar,KJ Craig,

For similar chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents: neurotransmitter uptake inhibitors: serotonin uptake inhibitors research abstracts see: chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents: neurotransmitter uptake inhibitors: serotonin uptake inhibitors research

PUBMED ID PMID:

MEDLINE DATE:

Obsessive-compulsive disorder: boundary issues. Journal Published:

PUBLICATION TYPE: Review

Journal: CNS spectrums

VOLUME: 12

Page Numbers: 359-64, 367-375

Journal Abbreviation:

ISSN: 1092-8529

DAY: 3

MONTH: May

YEAR: 2007

Obsessive-compulsive disorder: boundary issues. Information

Number of References: 170

LANGUAGE: eng

NlmUniqueID: 9702877

Obsessive-compulsive disorder: boundary issues. Keywords Mesh Terms:

KEYWORDS: Serotonin Uptake Inhibitors

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Obsessive-compulsive disorder: boundary issues. Information

Substance Name: Serotonin Uptake Inhibitors

Registry Number: 0

Grant and Affiliation Information for Obsessive-compulsive disorder: boundary issues.

AFFILIATION: Postgraduate School of Medicine, University of Hertfordshire, Gueen Elizabeth II Hospital, Welwyn Garden City, UK. kim.fox@hpt.nhs.uk

Country: United States

AGENCY: United States NIMH

GRANT: 5R01 MH69433-03

ACRONYM: MH

MEDLINETA: CNS Spectr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Obsessive-compulsive disorder: boundary issues Related Publications

• Acuity and case management: a healthy dose of outcomes, part I.
• Acuity and case management: a healthy dose of outcomes, part III.
• Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: pathogenic or protective?
• Antibiotics for acute pyelonephritis in children.
• Characterization and in vitro cytotoxicity testing of ethanolamine-derived cadmium chelating agents.
• Coincidence of actin filaments and talin is required to activate vinculin.
• Corticosteroid therapy for nephrotic syndrome in children.
• Differential var gene expression in the organs of patients dying of falciparum malaria.
• Effects of training community staff in interventions for substance misuse in dual diagnosis patients with psychosis (COMO study): cluster randomised trial.
• Exploring the challenges and successes of the Lecturer Practitioner role using a stakeholder evaluation approach.
• Health professionals' perceptions of feeding-related quality of life in children with quadriplegic cerebral palsy.
• Hollow-fibre affinity cell separation.
• How to provide transcutaneous pacing.
• Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.
• Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents.
• Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.
• J-protein co-chaperone Sis1 required for generation of [RNQ+] seeds necessary for prion propagation.
• KRIP6: a novel BTB/kelch protein regulating function of kainate receptors.
• Laser-evoked potentials are graded and somatotopically organized anteroposteriorly in the operculoinsular cortex of anesthetized monkeys.
• N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells.
• Network of general and specialty J protein chaperones of the yeast cytosol.
• Obsessive-compulsive disorder: boundary issues.
• Physical organic chemistry of supramolecular polymers.
• Prevalence of CYP1B1 mutations in Australian patients with primary congenital glaucoma.
• Retrograde analyses of spinothalamic projections in the macaque monkey: input to ventral posterior nuclei.
• Reversibly cross-linked surface-grafted polymer brushes.
• Strategies for improving pneumococcal vaccination in eligible patients.
• Take charge with an automated external defibrillator.
• The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.
• [Mixed infection of Echinococcus granulosus and Echinococcus multilocularis in dog]