[Observation of the effect of hyperoxic sodium chloride solution on hypoxic injury]

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[Observation of the effect of hyperoxic sodium chloride solution on hypoxic injury] Abstract Text:

Yong-Hua Sun,Xiao-Hua Hu,Zhong Chen,An-Yuan Cheng,Sui-Hang Zhong,

OBJECTIVE: To observe and explore the effects of compound hyperoxic sodium chloride solution on the management of burn shock. METHODS: (1) Wistar rats were randomly divided into 6 groups, i.e. A group (normal rats as control), B and C groups (the rats of 30% TBSA full thickness burn with compound sodium chloride solution at 1 and 6 postburn hours (PBHs) respectively); D and E groups (with hyperoxic sodium chloride solution at 1 and 6 PBHs respectively), and F group (without treatment). The changes in the serum contents of LPS, IL-6, DAO, D-lactate and MDA in the rats of each group were observed dynamically. (2) The burn patients admitted within 3 PBHs with 50% - 69% TBSA burns were enrolled in the study and were randomly divided into the treatment (with hyperoxic sodium chloride solution) and the control (with sodium chloride solution) groups, The changes during shock stage, the postburn complications and the changes in the PtcO(2) and the serum contents of Hb, Hct were observed. RESULTS: All indices examined in B, C, D and E groups were evidently higher than those in A group in a progressive manner, especially in F group. The sequence was as follows: F group > C group > B group > E group > D group (P < 0.05). The patients in treatment group could undergo the shock stage more steadily with decreased ammount of fluid infusion and increased PO(2) and less complications when compared with those in control group. But there was no obvious difference of the content of blood oxygen saturation between the two groups. CONCLUSION: Application of hyperoxic sodium chloride solution during the early postburn stage could be beneficial to the management of burn shock.

[Observation of the effect of hyperoxic sodium chloride solution on hypoxic injury] Publishing Authors By Initials

YH Sun,XH Hu,Z Chen,AY Cheng,SH Zhong,

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[Observation of the effect of hyperoxic sodium chloride solution on hypoxic injury] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang za

VOLUME: 19 Suppl

Page Numbers: 22-6

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ISSN: 1009-2587

DAY: 22

MONTH: Nov

YEAR: 2003

[Observation of the effect of hyperoxic sodium chloride solution on hypoxic injury] Information

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LANGUAGE: chi

NlmUniqueID: 100959418

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Grant and Affiliation Information for [Observation of the effect of hyperoxic sodium chloride solution on hypoxic injury]

AFFILIATION: Department of Burns, Beijing Ji Shui Tan Hospital, Beijing 100035, P.R. China.

Country: China

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MEDLINETA: Zhonghua Shao Shang Za Zhi

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