[Observation of long-term therapeutic outcome in chronic granulocytic leukemia]

[Observation of long-term therapeutic outcome in chronic granulocytic leukemia] Research Abstract Details 

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[Observation of long-term therapeutic outcome in chronic granulocytic leukemia] Abstract Text:

B Liu,Y Wang,C Hao,Y Liu,L Qian,

OBJECTIVE: To analyse the long-term outcome of various therapeutic protocol for the treatment of chronic granulocytic leukemia (CGL). METHODS: Median duration of chronic phase, survival and transformation of 331 CGL patients treated with different project were retrospectively analyzed. RESULT: Longer chronic phase and survival and lower percentage of transformation were found in patients using mesoindigo as maintaining treatment as compared with those using busulfan as maintaining treatment. The effect of meisoindigo and hydroxyurea showed no significant difference. These two drugs were both superior to bulsufan. Combination chemotherapy was not superior to meisoindigo, hydroxyurea or busulfan alone. Interferon had the best therapeutic effectiveness for the treatment of CGL. CONCLUSION: Busulfan was not suitable for maintaining treatment. Meisoindigo or meisoindigo combined with hydroxyurea was good choices for maintaining treatment. Meisoindigo and hydroxyurea had better effect in combination than alone. Interferon could significantly prolong the chronic period and survival period of CGL patients.

[Observation of long-term therapeutic outcome in chronic granulocytic leukemia] Publishing Authors By Initials

B Liu,Y Wang,C Hao,Y Liu,L Qian,

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[Observation of long-term therapeutic outcome in chronic granulocytic leukemia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 22

Page Numbers: 61-3

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 5

MONTH: Feb

YEAR: 2001

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Institute of Hematology, CAMS and PUMC, Tianjin 300020, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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