Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.

Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Research Abstract Details 

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Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Abstract Text:

Sarah B Geisler,Dustin Robinson,Maria Hauringa,Maide O Raeker,Andrei B Borisov,Margaret V Westfall,Mark W Russell,

Cytoskeletal adaptor proteins serve vital functions in linking the internal cytoskeleton of cells to the cell membrane, particularly at sites of cell-cell and cell-matrix interactions. The importance of these adaptors to the structural integrity of the cell is evident from the number of clinical disease states attributable to defects in these networks. In the heart, defects in the cytoskeletal support system that surrounds and supports the myofibril result in dilated cardiomyopathy and congestive heart failure. In this study, we report the cloning and characterization of a novel cytoskeletal adaptor, obscurin-like 1 (OBSL1), which is closely related to obscurin, a giant structural protein required for sarcomere assembly. Multiple isoforms arise from alternative splicing, ranging in predicted molecular mass from 130 to 230 kDa. OBSL1 is located on human chromosome 2q35 within 100 kb of SPEG, another gene related to obscurin. It is expressed in a broad range of tissues and localizes to the intercalated discs, to the perinuclear region, and overlying the Z lines and M bands of adult rat cardiac myocytes. Further characterization of this novel cytoskeletal linker will have important implications for understanding the physical interactions that stabilize and support cell-matrix, cell-cell, and intracellular cytoskeletal connections.

Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Publishing Authors By Initials

SB Geisler,D Robinson,M Hauringa,MO Raeker,AB Borisov,MV Westfall,MW Russell,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genomics

VOLUME: 89

Page Numbers: 521-31

Journal Abbreviation: Genomics

ISSN: 0888-7543

DAY: 6

MONTH: 02

YEAR: 2007

Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Information

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LANGUAGE: eng

NlmUniqueID: 8800135

Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: chemistry

Chemical & Substance for Abstract: Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Information

Substance Name: OBSL1 protein, rat

Registry Number: 0

Grant and Affiliation Information for Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.

AFFILIATION: Department of Pediatrics and Communicable Diseases, University of Michigan, L1242 Women's Hospital/Box 0204, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0204, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL075093-01A1

ACRONYM: HL

MEDLINETA: Genomics

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