Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs.

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Abstract Text:

Raymond K Kudej,You-Tang Shen,Athanasios P Peppas,Cheng-Hsiung Huang,Wei Chen,Lin Yan,Dorothy E Vatner,Stephen F Vatner,

We tested the hypothesis that cardiac nerves may mediate ischemic preconditioning. Pigs were chronically instrumented to measure aortic, left atrial and left ventricular pressures, and regional myocardial function (wall thickening). Hemodynamic variables, area at risk, and tissue blood flows (radioactive microspheres) were similar among groups. Myocardial infarct size following 60 minutes coronary artery occlusion and 4 days reperfusion, expressed as a fraction of the area at risk, was 42+/-4.0%, in innervated pigs and similar in pigs with regional cardiac denervation (CD, 41+/-2.5%). Infarct size in innervated pigs during the first window of preconditioning (first window) was markedly reduced (6+/-1.8%, P<0.01), as it was in the second window of preconditioning (second window) (16+/-3.3%, P<0.01). Although infarct size was still reduced in pigs with CD and first window preconditioning (9+/-1.8%, P<0.01), the protective effects of second window were abrogated in pigs with CD resulting in an infarct size of 38+/-5.6%. In another group of innervated pigs during pharmacological alpha(1)-adrenergic receptor (AR) blockade, infarct size was also not reduced during the second window (48+/-3.2%). Additionally, Western blot analysis of inducible nitric oxide synthase and cyclooxygenase-2 proteins demonstrated significant (P<0.05) upregulation following the second window in innervated pigs, but not in pigs with CD or alpha(1)-AR blockade. Thus, the mechanism of protection during the second window, but not the first window, appears to be dependent on cardiac nerves and alpha(1)-AR stimulation.

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Publishing Authors By Initials

RK Kudej,YT Shen,AP Peppas,CH Huang,W Chen,L Yan,DE Vatner,SF Vatner,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

PUBMED ID PMID:

MEDLINE DATE:

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Circulation research

VOLUME: 99

Page Numbers: 1270-6

Journal Abbreviation: Circ. Res.

ISSN: 1524-4571

DAY: 26

MONTH: 10

YEAR: 2006

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 47103

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: metabolism

Chemical & Substance for Abstract: Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Information

Substance Name: Cyclooxygenase 2

Registry Number: EC 1.14.99.1

Grant and Affiliation Information for Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs.

AFFILIATION: Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, UMDNJ-New Jersey Medical School, Newark 07103, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL59139

ACRONYM: HL

MEDLINETA: Circ Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs Related Publications

• Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha.
• Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism.
• Cardioprotection in stunned and hibernating myocardium.
• Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart.
• Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.
• Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates.
• Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs.
• Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.
• Sex differences in myocardial infarction and rupture.
• Type 5 adenylyl cyclase disruption increases longevity and protects against stress.