Obesity induces a phenotypic switch in adipose tissue macrophage polarization.

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Research Abstract Details 

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Abstract Text:

Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon high-fat feeding may differ from those that reside there under normal diet conditions. To this end, we found a novel F4/80(+)CD11c(+) population of ATMs in adipose tissue of obese mice that was not seen in lean mice. ATMs from lean mice expressed many genes characteristic of M2 or "alternatively activated" macrophages, including Ym1, arginase 1, and Il10. Diet-induced obesity decreased expression of these genes in ATMs while increasing expression of genes such as those encoding TNF-alpha and iNOS that are characteristic of M1 or "classically activated" macrophages. Interestingly, ATMs from obese C-C motif chemokine receptor 2-KO (Ccr2-KO) mice express M2 markers at levels similar to those from lean mice. The antiinflammatory cytokine IL-10, which was overexpressed in ATMs from lean mice, protected adipocytes from TNF-alpha-induced insulin resistance. Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Publishing Authors By Initials

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 175-84

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 3

MONTH: Jan

YEAR: 2007

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802877

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Keywords Mesh Terms:

KEYWORDS: Reverse Transcriptase Polymerase Chain R

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Information

Substance Name: Deoxyglucose

Registry Number: 154-17-6

Grant and Affiliation Information for Obesity induces a phenotypic switch in adipose tissue macrophage polarization.

AFFILIATION: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

Country: United States

AGENCY: United States NICHD

GRANT: T32 HD 007513-07

ACRONYM: HD

MEDLINETA: J Clin Invest

REFSOURCE: J Clin Invest. 2007 Jan;117(1):89-93

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