Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat.

Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat. Research Abstract Details 

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Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat. Abstract Text:

David W Stepp,Erika I Boesen,Jennifer C Sullivan,James D Mintz,Clark D Hair,David M Pollock,David W Stepp,Erika I Boesen,Jennifer C Sullivan,James D Mintz,Clark D Hair,David M Pollock,

Obesity is an emerging risk factor for renal dysfunction, but the mechanisms are poorly understood. Obese patients show heightened renal vasodilation to blockade of the renin-angiotensin system, suggesting deficits in vascular responses to angiotensin II (ANG II). This study tested the hypothesis that obesity augments renal vasoconstriction to ANG II. Lean (LZR), prediabetic obese (OZR), and nonobese fructose-fed Zucker rats (FF-LZR) were studied to determine the effects of obesity and insulin resistance on reactivity of blood pressure and renal blood flow to vasoconstrictors. OZR showed enlargement of the kidneys, elevated urine output, increased sodium intake, and decreased plasma renin activity (PRA) vs. LZR, and renal vasoconstriction to ANG II was augmented in OZR. Renal reactivity to norepinephrine and mesenteric vascular reactivity to ANG II were similar between LZR and OZR. Insulin-resistant FF-LZR had normal reactivity to ANG II, indicating the insulin resistance was an unlikely explanation for the changes observed in OZR. Four weeks on a low-sodium diet (0.08%) to raise PRA reduced reactivity to ANG II in OZR back to normal levels without effect on LZR. From these data, we conclude that in the prediabetic stages of obesity, a decrease in PRA is observed in Zucker rats that may lead to increased renal vascular reactivity to ANG II. This increased reactivity to ANG II may explain the elevated renal vasodilator effects observed in obese humans and provide insight into early changes in renal function that predispose to nephropathy in later stages of the disease.

Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat. Publishing Authors By Initials

DW Stepp,EI Boesen,JC Sullivan,JD Mintz,CD Hair,DM Pollock,DW Stepp,EI Boesen,JC Sullivan,JD Mintz,CD Hair,DM Pollock,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasoconstrictor agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasoconstrictor agents research

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Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Heart and circulat

VOLUME: 293

Page Numbers: H2537-42

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 10

MONTH: 08

YEAR: 2007

Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901228

Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat. Keywords Mesh Terms:

KEYWORDS: Vasoconstrictor Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat.

AFFILIATION: Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd., Augusta, GA 30912, USA. dstepp@mcg.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL-76533

ACRONYM: HL

MEDLINETA: Am J Physiol Heart Circ Physio

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