Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.

Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Abstract Text:

R Samuel Rajendran,Marianne M Zupanc,Andreas ,Jurjen Westra,Jerold Chun, Zupanc,

Teleost fish are distinguished by their enormous potential for the generation of new cells in both the intact and the injured adult brain. Here, we present evidence that these cells are a genetic mosaic caused by somatic genomic alteration. Metaphase chromosome spreads from whole brains of the teleost Apteronotus leptorhynchus revealed an euploid complement of 22 chromosomes in only 22% of the cells examined. The rate of aneuploidy is substantially higher in brain cells than in liver cells, as shown by both metaphase chromosome spreads and flow cytometric analysis. Among the aneuploid cells in the brain, approximately 84% had fewer, and the remaining 16% more, than 22 chromosomes. Typically, multiple chromosomes were lost or gained. The aneuploidy is putatively caused by segregation defects during mitotic division. Labeling of condensed chromosomes of M-phase cells by phosphorylated histone-H3 revealed laggards, anaphase bridges, and micronuclei, all three of which indicate displaced mitotic chromosomes. Quantitative analysis has shown that in the entire brain on average 14% of all phosphorylated histone-H3-labeled cells exhibit such signs of segregation defects. Together with the recent discovery of aneuploidy in the adult mammalian brain, the results of the present investigation suggest that the loss or gain of chromosomes might provide a mechanism to regulate gene expression during development of new cells in the adult vertebrate brain.

Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Publishing Authors By Initials

RS Rajendran,MM Zupanc,A ,J Westra,J Chun,GK Zupanc,

For similar cells: stem cells research abstracts see: cells: stem cells research

PUBMED ID PMID:

MEDLINE DATE:

Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental neurobiology

VOLUME: 67

Page Numbers: 1334-47

Journal Abbreviation: Dev Neurobiol

ISSN: 1932-8451

DAY: 1

MONTH: Sep

YEAR: 2007

Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101300215

Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Information

Substance Name: Histones

Registry Number: 0

Grant and Affiliation Information for Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.

AFFILIATION: School of Engineering and Science, Jacobs University Bremen, D-28725 Bremen, Germany.

Country: United States

AGENCY: United States NIMH

GRANT: MH076145

ACRONYM: MH

MEDLINETA: Dev Neurobiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish Related Publications

• Apoptotic cell death, long-term persistence, and neuronal differentiation of aneuploid cells generated in the adult brain of teleost fish.
• Evidence for D0-D0 mixing.
• Experimental constraints on the spin and parity of the Lambdac(2880)+.
• Integrative and comparative neurobiology: in memoriam of Theodore H. Bullock (1915-2005).
• Measurement of D0-D0 mixing parameters in D0 --> Ks pi+ pi- decays.
• Measurement of Einstein-Podolsky-Rosen-type flavor entanglement in Upsilon(4S) --> B0 B0 decays.
• Measurement of the e;{+}e;{-}-->pi;{+}pi;{-}J/psi Cross Section Via Initial-State Radiation at Belle.
• Measurement of the tau lepton mass and an upper limit on the mass difference between tau+ and tau-.
• Measurements of branching fractions for B --> K pi and B --> pi pi decays.
• Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.
• Observation of Anomalous Upsilon(1S)pi;{+}pi;{-} and Upsilon(2S)pi;{+}pi;{-} Production near the Upsilon(5S) Resonance.
• Observation of B;{0}-->D;{*-}tau;{+}nu_{tau} Decay at Belle.
• Observation of B;{0}-->pp[over ]K;{*0} with a Large K;{*0} Polarization.
• Observation of direct CP violation in B0 --> pi+pi- decays and model-independent constraints on the quark-mixing angle phi2.
• Observation of the psi(4415)-->DD[over ]_{2};{*}(2460) Decay Using Initial-State Radiation.
• Observation of two resonant structures in e+ e- -->pi+ pi- psi(2S) via initial-state radiation at Belle.
• Search for B-->h;{(*)}nunu[over ] Decays at Belle.
• Search for the CP-Violating Decays Upsilon(4S)-->B;{0}B[over ];{0}-->J/psiK_{S};{0}+J/psi(eta_{c})K_{S};{0}.
• Theodore H. Bullock: pioneer of integrative and comparative neurobiology.