Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I.

Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Research Abstract Details 

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Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Abstract Text:

P-J Bousquet,R Hooper,M Kogevinas,D Jarvis,P Burney,

BACKGROUND: Many clinical and epidemiological studies have measured the prevalence of IgE sensitization using skin tests and/or serum-specific IgE. Most of them have been done in only one country using a battery of selected allergens relevant to that country. In multi-centre studies, the number of tested allergens is often limited by the cost. It is therefore difficult to compare prevalence of sensitized subjects between studies. OBJECTIVE: To define the number and the type of allergen that should be tested in order to characterize a person as sensitized. METHOD: Subjects were selected from the European Community Respiratory Health Survey I. All subjects underwent skin prick tests to nine of the most common allergens. In addition, two local allergens were tested in some centres. RESULT: Using nine allergens, 35.6% of the 11 355 subjects were sensitized. The prevalence of sensitization increased with the number of tested allergens. Seven allergens enabled the identification of almost all sensitized subjects, adding another one inducing, in most countries, an increase of prevalence under 0.5%. Adding one local allergen to the battery of tests increased the overall estimated prevalence by only 1%. This increase was not seen in Ireland and was less marked in the United Kingdom (0.3%) but was greater in France (2.6%), Australia (2.5%) and Belgium (1.9%). CONCLUSION: Seven selected allergens (Dermatophagoides pteronyssinus, cat, grass, birch, olive pollen, Alternaria and Cladosporium) allow the identification of almost all sensitized subjects in epidemiologic studies. Inclusion of local allergen should be considered in a standard panel for international studies.

Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Publishing Authors By Initials

PJ Bousquet,R Hooper,M Kogevinas,D Jarvis,P Burney,

For similar diagnosis: diagnostic techniques and procedures: skin tests research abstracts see: diagnosis: diagnostic techniques and procedures: skin tests research

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MEDLINE DATE:

Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental allergy : journal of the

VOLUME: 37

Page Numbers: 780-7

Journal Abbreviation:

ISSN: 0954-7894

DAY: 3

MONTH: May

YEAR: 2007

Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8906443

Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Keywords Mesh Terms:

KEYWORDS: Skin Tests

MESH TERMS: methods

Chemical & Substance for Abstract: Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Information

Substance Name: Immunoglobulin E

Registry Number: 37341-29-0

Grant and Affiliation Information for Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I.

AFFILIATION: Imperial College, Emmanuel Kaye Building, London, UK.

Country: England

AGENCY: United States NCRR

GRANT: 2 S07 RR05521-28

ACRONYM: RR

MEDLINETA: Clin Exp Allergy

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