Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus).

Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Research Abstract Details 

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Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Abstract Text:

Austin L Hughes,Mary Ann K Hughes,

The K1 locus is a highly polymorphic locus in the genome of human herpesvirus 8, the causative agent of Kaposi's sarcoma. Analysis of the pattern of nucleotide substitution among alleles at this locus supported the hypothesis that natural selection has acted to enhance amino acid diversity in the two hypervariable regions (VR1 and VR2) of the extracellular portion of the K1 protein. A phylogenetic analysis of 125 complete K1 sequences revealed two major clades, designated A/C and B. There was strong evidence against recombination between VR1 and VR2 among alleles belonging to different clades, and little support for frequent recombination within clades. The pattern of diversification of VR1 and VR2 within clades was similar to that between clades, but the immunoreceptor tyrosine-based activation motif (ITAM)-like sequence in the cytoplasmic region of K1 showed strong divergence between clades despite conservation within clades. The latter finding suggests that, while being subject to similar selection favoring diversity in the extracellular region, the two major clades of K1 alleles may be adapted for different types of interaction with host intracellular signal transduction mechanisms.

Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Publishing Authors By Initials

AL Hughes,MA Hughes,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Infection, genetics and evolution : journal of mol

VOLUME: 7

Page Numbers: 110-5

Journal Abbreviation: Infect. Genet. Evol.

ISSN: 1567-1348

DAY: 24

MONTH: 07

YEAR: 2006

Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Information

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LANGUAGE: eng

NlmUniqueID: 101084138

Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus).

AFFILIATION: Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, United States. austin@biol.sc.edu

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM43940

ACRONYM: GM

MEDLINETA: Infect Genet Evol

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