Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.

Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. Research Abstract Details 

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Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. Abstract Text:

Kenatarou Watanabe,Toyofusa Katou,Yasunori Ikezawa,Saki Yajima,Hirohito Shionoya,Takashi Akagi,Keita Hamasaki,

Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied. Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA. The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.

Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. Publishing Authors By Initials

K Watanabe,T Katou,Y Ikezawa,S Yajima,H Shionoya,T Akagi,K Hamasaki,

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Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 209-10

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. Information

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LANGUAGE: eng

NlmUniqueID: 101259965

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Grant and Affiliation Information for Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.

AFFILIATION: Shibaura institute of technology, Department of applied chemistry, Toyosu 3-7-5, Koutou-ku, Tokyo 138-8548, Japan.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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