Nucleobase catalysis in ribozyme mechanism.

Nucleobase catalysis in ribozyme mechanism. Research Abstract Details 

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Nucleobase catalysis in ribozyme mechanism. Abstract Text:

Philip C Bevilacqua,Rieko Yajima,

RNA performs a wide range of functions in biology including catalysis of chemical reactions. A major goal in the field of ribozyme chemical biology is to understand these functions in molecular terms. There is increasing evidence that ribozymes can use their nucleobases directly in chemical catalysis in a variety of ways. These include hydrogen bonding to the transition state, stabilizing charge development, and transferring protons as general acid-base catalysts. This article highlights recent kinetic, structural, single molecule, and synthetic approaches that have been used to probe the roles of ribozyme nucleobases in phosphodiester bond cleavage.

Nucleobase catalysis in ribozyme mechanism. Publishing Authors By Initials

PC Bevilacqua,R Yajima,

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Nucleobase catalysis in ribozyme mechanism. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in chemical biology

VOLUME: 10

Page Numbers: 455-64

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ISSN: 1367-5931

DAY: 28

MONTH: 08

YEAR: 2006

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LANGUAGE: eng

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Grant and Affiliation Information for Nucleobase catalysis in ribozyme mechanism.

AFFILIATION: Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA. pcb@chem.psu.edu

Country: England

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MEDLINETA: Curr Opin Chem Biol

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