Nucleic acid oxidation in Alzheimer disease.

Nucleic acid oxidation in Alzheimer disease. Research Abstract Details 

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Nucleic acid oxidation in Alzheimer disease. Abstract Text:

Paula I Moreira,Akihiko Nunomura,Masao Nakamura,Atsushi Takeda,Justin C Shenk,Gjumrakch Aliev,Mark A Smith,George Perry,

Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed.

Nucleic acid oxidation in Alzheimer disease. Publishing Authors By Initials

PI Moreira,A Nunomura,M Nakamura,A Takeda,JC Shenk,G Aliev,MA Smith,G Perry,

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Nucleic acid oxidation in Alzheimer disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Free radical biology & medicine

VOLUME: 44

Page Numbers: 1493-505

Journal Abbreviation: Free Radic. Biol. Med.

ISSN: 0891-5849

DAY: 18

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 8709159

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Grant and Affiliation Information for Nucleic acid oxidation in Alzheimer disease.

AFFILIATION: Center for Neuroscience and Cell Biology, Institute of Physiology-Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Country: United States

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MEDLINETA: Free Radic Biol Med

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