Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer.

Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Research Abstract Details 

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Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Abstract Text:

Hiroyuki Namba,Vladimir Saenko,Shunichi Yamashita,

Apoptosis is an essential physiological process of elimination of destined cells during the development and differentiation or after damage from external stresses such as ionizing radiation or chemotherapeutic agents. Disruption of apoptosis is proved to cause various diseases including cancer. Among numerous molecules involved in diverse anti- or pro-apoptotic signaling pathways, NF-kappaB is one of the key factors controlling anti-apoptotic responses. Its anti-apoptotic effect is thought to be mediated through not only transcriptional activation of dependent genes but also by crosstalking with the JNK pathway. Oncogenic proteins such as Ret/PTC, Ras and BRAF can induce NF-kappaB activation making it an important change in thyroid cancer. A number of specific or non-specific NF-kappaB inhibitors have been tried to take over the cascade in in vitro and in vivo experiments. These agents can induce massive apoptosis especially in combination with radio- or chemotherapy. Current results suggest that the inhibition of the NF-kappaB may be a promising strategy for advanced thyroid cancer treatment but further investigations are warranted to develop specific and clinically effective NF-kappaB inhibitors in future.

Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Publishing Authors By Initials

H Namba,V Saenko,S Yamashita,

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Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Arquivos brasileiros de endocrinologia e metabolog

VOLUME: 51

Page Numbers: 843-51

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ISSN: 0004-2730

DAY: 24

MONTH: Jul

YEAR: 2007

Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer.

AFFILIATION: Department of Molecular Medicine, Nagasaki University, Graduate School of Biomedical Sciences, Japan. namba@nagasaki-u.ac.jp

Country: Brazil

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MEDLINETA: Arq Bras Endocrinol Metabol

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