Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis.

Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Abstract Text:

Noriko Hotta,Takashi Ichiyama,Masahiro Shiraishi,Tsuyoshi Takekawa,Tomoyo Matsubara,Susumu Furukawa,

OBJECTIVE: To determine the activation of nuclear factor-[kappa]B in peripheral blood CD14+ monocyte/macrophages and CD3+, CD4+, and CD8+ T cells in children with sepsis. DESIGN: Observational study. SETTING: University hospital. PATIENTS: Twenty-six children with sepsis (nine females and 17 males, aged between 10 days and 15 yrs; median, 4.3 yrs) on admission to our hospital between August 1999 and November 2005. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The percentages of peripheral blood CD14+ monocyte/macrophages and CD3+, CD4+, and CD8+ T cells exhibiting nuclear factor-[kappa]B activity were determined by flow cytometry. In addition, relationships among the degree to which nuclear factor-[kappa]B was activated, serum levels of cytokines (interferon-[gamma], tumor necrosis factor-[alpha], interleukin-2, interleukin-4, interleukin-6, and interleukin-10), and clinical variables were analyzed. The percentage of cells exhibiting nuclear factor-[kappa]B activity was increased among CD14+, CD3+, CD4+, and CD8+ cells in the sepsis group and was significantly higher among CD14+, CD3+, and CD4+ cells of the patients with severe sepsis (n = 9) than those of patients with nonsevere sepsis (n = 17). The percentage of cells exhibiting nuclear factor-[kappa]B activity was significantly higher among CD14+ cells than CD3+ cells in the patients with severe sepsis. In addition, this percentage was significantly higher among CD14+ cells than CD3+, CD4+, and CD8+ cells in septic patients who had positive blood cultures (n = 16). Serum interleukin-6 levels were correlated with the percentages of CD14+, CD3+, CD4+, and CD8+ cells exhibiting nuclear factor-[kappa]B activity, and serum IL-10 levels were correlated with the percentages of CD14+, CD3+, and CD4+ cells exhibiting nuclear factor-[kappa]B activity. CONCLUSIONS: Nuclear factor-[kappa]B in peripheral blood mononuclear cells was activated in children with sepsis and was related the severity of sepsis.

Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Publishing Authors By Initials

N Hotta,T Ichiyama,M Shiraishi,T Takekawa,T Matsubara,S Furukawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Critical care medicine

VOLUME: 35

Page Numbers: 2395-401

Journal Abbreviation: Crit. Care Med.

ISSN: 0090-3493

DAY: 27

MONTH: Oct

YEAR: 2007

Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 355501

Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis.

AFFILIATION: Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Crit Care Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis Related Publications

• Biogeochemical consequences of macrofauna burrow ventilationdagger.
• Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: A double-blind, placebo-controlled clinical trial.
• Comparison of sleep parameters at titration and subsequent compliance between CPAP-pretreated and non-CPAP-pretreated patients with obstructive sleep apnea.
• E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1.
• Emotional distress and its correlates among parents of children with pervasive developmental disorders.
• Enhancement of in vitro and in vivo anti-tumor activity of anti-GD2 monoclonal antibody 220-51 against human neuroblastoma by granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.
• Evaluation of diagnostic criteria for panic attack using item response theory: Findings from the National Comorbidity Survey in USA.
• Evaluation of optimal drug concentration in histoculture drug response assay in association with clinical efficacy for head and neck cancer.
• Feasibility of a membrane-aerated biofilm reactor to achieve single-stage autotrophic nitrogen removal based on Anammox.
• Functional roles of Otx2 transcription factor in postnatal mouse retinal development.
• Further observation of content uniformity of d-alpha-tocopheryl acetate as an oily drug in granules obtained by wet granulation with a high-shear mixer.
• Ictal electroencephalographic correlates of posttreatment neuropsychological changes in electroconvulsive therapy: a hypothesis-generation study.
• In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer.
• Independent associations of alexithymia and social support with depression in hemodialysis patients.
• Intra-arterial chemotherapy less intensive than RADPLAT with concurrent radiotherapy for resectable advanced head and neck squamous cell carcinoma: a prospective study.
• Mechanisms of neuronal death in synucleinopathy.
• Middle Turbinate Fenestration Method: A New Technique for the Treatment of Olfactory Disturbance due to Chronic Sinusitis.
• Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas.
• Nevoid basal cell carcinoma syndrome successfully treated with trichloroacetic acid and phenol peeling.
• Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis.
• Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease.
• Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study.
• Reliability and validity of the Japanese version of the Dysexecutive Questionnaire (DEX) in Alzheimer's disease: validation of a behavioral rating scale to assess dysexecutive symptoms in Japanese patients with Alzheimer's disease.
• Retinal blood oxygen saturation mapping by multispectral imaging and morphological angiography.
• Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro.
• Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.
• The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.
• The new GRID Hamilton Rating Scale for Depression demonstrates excellent inter-rater reliability for inexperienced and experienced raters before and after training.
• Two dimensions of anosognosia in patients with Alzheimer's disease: Reliability and validity of the Japanese version of the Anosognosia Questionnaire for Dementia (AQ-D).
• Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children.