Nuclear entry of nonviral vectors.

Nuclear entry of nonviral vectors. Research Abstract Details 

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Nuclear entry of nonviral vectors. Abstract Text:

Nonviral gene delivery is limited to a large extent by multiple extracellular and intracellular barriers. One of the major barriers, especially in nondividing cells, is the nuclear envelope. Once in the cytoplasm, plasmids must make their way into the nucleus in order to be expressed. Numerous studies have demonstrated that transfections work best in dividing populations of cells in which the nuclear envelope disassembles during mitosis, thus largely eliminating the barrier. However, since many of the cells that are targets for gene therapy do not actively undergo cell division during the gene transfer process, the mechanisms of nuclear transport of plasmids in nondividing cells are of critical importance. In this review, we summarize recent studies designed to elucidate the mechanisms of plasmid nuclear import in nondividing cells and discuss approaches to either exploit or circumvent these processes to increase the efficiency of gene transfer and therapy.

Nuclear entry of nonviral vectors. Publishing Authors By Initials

For similar genetic structures: plasmids research abstracts see: genetic structures: plasmids research

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Nuclear entry of nonviral vectors. Journal Published:

PUBLICATION TYPE: Review

Journal: Gene therapy

VOLUME: 12

Page Numbers: 881-90

Journal Abbreviation: Gene Ther.

ISSN: 0969-7128

DAY: 28

MONTH: Jun

YEAR: 2005

Nuclear entry of nonviral vectors. Information

Number of References: 87

LANGUAGE: eng

NlmUniqueID: 9421525

Nuclear entry of nonviral vectors. Keywords Mesh Terms:

KEYWORDS: Plasmids

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Nuclear entry of nonviral vectors. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Nuclear entry of nonviral vectors.

AFFILIATION: Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Country: England

AGENCY: United States NHLBI

GRANT: R01 HL059956-07

ACRONYM: HL

MEDLINETA: Gene Ther

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