Nuclear Ca(2+) sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes.

Nuclear Ca(2+) sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Research Abstract Details 

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Nuclear Ca(2+) sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Abstract Text:

Dali Luo,Dongmei Yang,Xiaomei Lan,Kaitao Li,Xiaodong Li,Ju Chen,Youyi Zhang,Rui-Ping Xiao,Qide Han,Heping Cheng,Dali Luo,Dongmei Yang,Xiaomei Lan,Kaitao Li,Xiaodong Li,Ju Chen,Youyi Zhang,Rui-Ping Xiao,Qide Han,Heping Cheng,

Dynamic nuclear Ca(2+) signals play pivotal roles in diverse cellular functions including gene transcription, cell growth, differentiation, and apoptosis. Here we report a novel nuclear Ca(2+) regulatory mechanism mediated by inositol 1,4,5-trisphosphate receptors (IP(3)Rs) around the nucleus in developing cardiac myocytes. Activation of IP(3)Rs by alpha(1)-adrenergic receptor (alpha(1)AR) stimulation or by IP(3) application (in saponin-permeabilized cells) increases Ca(2+) spark frequency preferentially in the region around the nucleus in neonatal rat ventricular myocytes. A nuclear enrichment of IP(3)R distribution supports the higher responsiveness of Ca(2+) release in this particular region. Strikingly, we observed "nuclear Ca(2+)waves" that engulf the entire nucleus without spreading into the bulk cytosol. alpha(1)AR stimulation enhances the occurrence of nuclear Ca(2+) waves and confers them the ability to trigger cytosolic Ca(2+) waves via IP(3)R-dependent pathways. This finding accounts, at least partly, for a profound frequency-dependent modulation of global Ca(2+) oscillations during alpha(1)AR stimulation. Thus, IP(3)R-mediated Ca(2+) waves traveling in the nuclear region provide active, autonomous regulation of nuclear Ca(2+) signaling, which provides for not only the local signal transduction, but also a pacemaker to drive global Ca(2+) transient in the context of alpha(1)AR stimulation in developing cardiac myocytes.

Nuclear Ca(2+) sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Publishing Authors By Initials

D Luo,D Yang,X Lan,K Li,X Li,J Chen,Y Zhang,RP Xiao,Q Han,H Cheng,D Luo,D Yang,X Lan,K Li,X Li,J Chen,Y Zhang,RP Xiao,Q Han,H Cheng,

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Nuclear Ca(2+) sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell calcium

VOLUME: 43

Page Numbers: 165-74

Journal Abbreviation: Cell Calcium

ISSN: 0143-4160

DAY: 20

MONTH: 06

YEAR: 2007

Nuclear Ca(2+) sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Information

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LANGUAGE: eng

NlmUniqueID: 8006226

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Grant and Affiliation Information for Nuclear Ca(2+) sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes.

AFFILIATION: Department of Pharmacology, School of Chemical Biology & Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China; Institute of Cardiovascular Science at Health Science Center, Peking University, Beijing 100083, China.

Country: Scotland

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MEDLINETA: Cell Calcium

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