NSAIDs and cancer prevention: targets downstream of COX-2.

NSAIDs and cancer prevention: targets downstream of COX-2. Research Abstract Details 

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NSAIDs and cancer prevention: targets downstream of COX-2. Abstract Text:

Yong I Cha,Raymond N DuBois,

Preclinical and clinical studies have clearly shown a benefit of nonsteroidal anti-inflammatory drug (NSAID) use in reducing cancer risk. However, the adverse gastrointestinal and cardiovascular side effects associated with NSAIDs and COX-2 selective inhibitors (coxibs) have provoked more scrutiny of the precise role of specific downstream mediators in the prostaglandin (PG) signaling cascade. NSAIDs and coxibs inhibit PG biosynthesis. One of the PGs produced at high levels in the tumor microenvironment is PGE(2), which is thought to play a major role in cancer progression. Thus, a better understanding of PGE(2) signaling could enable identification of novel and safer therapeutic targets downstream of the cyclooxygenase enzymes. We review the emerging molecular mechanisms by which COX-2-derived PGE(2) is involved in cancer progression and delineate potential opportunities for development of novel pharmacologic approaches utilizing this pathway.

NSAIDs and cancer prevention: targets downstream of COX-2. Publishing Authors By Initials

YI Cha,RN DuBois,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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MEDLINE DATE:

NSAIDs and cancer prevention: targets downstream of COX-2. Journal Published:

PUBLICATION TYPE: Review

Journal: Annual review of medicine

VOLUME: 58

Page Numbers: 239-52

Journal Abbreviation: Annu. Rev. Med.

ISSN: 0066-4219

DAY: 3

MONTH: 12

YEAR: 2007

NSAIDs and cancer prevention: targets downstream of COX-2. Information

Number of References: 84

LANGUAGE: eng

NlmUniqueID: 2985151

NSAIDs and cancer prevention: targets downstream of COX-2. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: NSAIDs and cancer prevention: targets downstream of COX-2. Information

Substance Name: Cyclooxygenase 2

Registry Number: EC 1.14.99.1

Grant and Affiliation Information for NSAIDs and cancer prevention: targets downstream of COX-2.

AFFILIATION: Department of Medicine, Cell and Developmental Biology and Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6838, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R37-DK47297

ACRONYM: DK

MEDLINETA: Annu Rev Med

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