NSAID use and survival after breast cancer diagnosis in post-menopausal women.

NSAID use and survival after breast cancer diagnosis in post-menopausal women. Research Abstract Details 

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NSAID use and survival after breast cancer diagnosis in post-menopausal women. Abstract Text:

Cindy K Blair,Carol Sweeney,Kristin E Anderson,Aaron R Folsom,

Many epidemiologic studies, although not all, have shown an inverse relation between non-steroidal anti-inflammatory drug (NSAID) use and risk of incident breast cancer, but the possible influence of NSAID use on breast cancer survival has not been evaluated. We examined the association between self-reported NSAID use and survival after invasive breast cancer diagnosis among 591 postmenopausal women in a prospective study. Cox proportional hazards regression was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for breast cancer death as well as all-cause mortality associated with NSAID use. There was an indication of reduced risk of breast cancer mortality and all-cause mortality for women reporting any versus no use of NSAIDs, with multivariate-adjusted HRs of 0.64 (95% CI 0.39-1.05) and 0.57 (95% CI 0.40-0.81), respectively. There was no trend of decreasing risk of death with increasing frequency of NSAID use per week. While the results from this exploratory analysis are preliminary, there is biological plausibility for such an association. Further studies should consider whether NSAIDs, which have biological activity affecting tumor promotion and progression and appear to protect against breast cancer incidence, may be associated with better prognosis after a diagnosis of invasive breast cancer.

NSAID use and survival after breast cancer diagnosis in post-menopausal women. Publishing Authors By Initials

CK Blair,C Sweeney,KE Anderson,AR Folsom,

For similar investigative techniques: epidemiologic methods: statistics as topic: survival analysis research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: survival analysis research

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MEDLINE DATE:

NSAID use and survival after breast cancer diagnosis in post-menopausal women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Breast cancer research and treatment

VOLUME: 101

Page Numbers: 191-7

Journal Abbreviation: Breast Cancer Res. Treat.

ISSN: 0167-6806

DAY: 6

MONTH: 07

YEAR: 2006

NSAID use and survival after breast cancer diagnosis in post-menopausal women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8111104

NSAID use and survival after breast cancer diagnosis in post-menopausal women. Keywords Mesh Terms:

KEYWORDS: Survival Analysis

MESH TERMS: prevention & control

Chemical & Substance for Abstract: NSAID use and survival after breast cancer diagnosis in post-menopausal women. Information

Substance Name: Anti-Inflammatory Agents, Non-Steroidal

Registry Number: 0

Grant and Affiliation Information for NSAID use and survival after breast cancer diagnosis in post-menopausal women.

AFFILIATION: University of Minnesota Cancer Center, Minneapolis, MN, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: R01 CA 39742

ACRONYM: CA

MEDLINETA: Breast Cancer Res Treat

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