NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs.

NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Research Abstract Details 

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NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Abstract Text:

Douglas J MacNeil,Douglas J MacNeil,

A combination of pharmacological and genetic studies in mice confirmed that the Y1 and Y5 receptors mediate the potent orexigenic actions of exogenous NPY. Although the physiological role of NPY in causing obesity is less clear, potent and selective antagonists of both Y1 and Y5 have been developed. Some of the NPY antagonists have suitable pharmacokinetic (PK) properties that allowed them to be evaluated in various rodent models of obesity. Several different Y1 and Y5 antagonists cause weight loss in rodent models, though confirmation that these effects are mechanism based has been limited. One Y5 antagonist, MK-0557 was evaluated in a 1-yr clinical trial and found to cause modest weight loss. Optimal NPY antagonist therapeutics for obesity may require blockade of both the Y1 and Y5 receptors.

NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Publishing Authors By Initials

DJ MacNeil,DJ MacNeil,

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NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current topics in medicinal chemistry

VOLUME: 7

Page Numbers: 1721-33

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ISSN: 1873-4294

DAY: 5

MONTH: 11

YEAR: 2007

NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Information

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LANGUAGE: eng

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Grant and Affiliation Information for NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs.

AFFILIATION: Merck Research Laboratories, 80M-213, Rahway, NJ 07065, USA. doug_macneil@merck.com

Country: Netherlands

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MEDLINETA: Curr Top Med Chem

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