Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera.

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Abstract Text:

Zeyu Xiong,Yan Yan,Enli Liu,Richard T Silver,Srdan Verstovsek,Fan Yang,Hong Wang,Josef Prchal,Xiao-Feng Yang,

We attempted to determine whether the immune reactions elicited by aberrantly expressed testis antigens contribute to the beneficial responses to interferon (IFN)-alpha therapy and other therapies in patients with polycythemia vera (PV). We screened a human testis cDNA library using SEREX (serological analysis of tumor antigens by screening an expression cDNA library with sera from three patients with PV who had undergone IFN-alpha-induced or other therapeutics-induced remission). We identified two novel PV associated tumor antigens, PV65 (eIF-2alpha) and PV13 (protamine 2). These 2 antigens elicited IgG antibody reactions in a subset of PV patients but not in healthy donors, suggesting that they are authentic tumor antigens. Increased phosphorylation of PV65 in response to stimulation of IFN-alpha, and upregulation of PV13 in tumor cells might enhance their abilities in elicitation of immune reactions in patients. These findings provide new insights into the mechanism underlying the regulation of the self-antigen repertoire in eliciting anti-tumor immune reactions in patients with polycythemia vera, and suggest their potential as the targets of novel immunotherapy.

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Publishing Authors By Initials

Z Xiong,Y Yan,E Liu,RT Silver,S Verstovsek,F Yang,H Wang,J Prchal,XF Yang,

For similar cells: cells, cultured: cell line: cell line, tumor: u937 cells research abstracts see: cells: cells, cultured: cell line: cell line, tumor: u937 cells research

PUBMED ID PMID:

MEDLINE DATE:

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical immunology (Orlando, Fla.)

VOLUME: 122

Page Numbers: 279-87

Journal Abbreviation: Clin. Immunol.

ISSN: 1521-6616

DAY: 17

MONTH: 11

YEAR: 2006

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883537

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Keywords Mesh Terms:

KEYWORDS: U937 Cells

MESH TERMS: immunology

Chemical & Substance for Abstract: Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Information

Substance Name: protamine 2

Registry Number: 0

Grant and Affiliation Information for Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera.

AFFILIATION: Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI054514

ACRONYM: AI

MEDLINETA: Clin Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera Related Publications

• Application of mucin quantitative competitive reverse transcription polymerase chain reaction in assisting the diagnosis of malignant pleural effusion.
• Aquaporin gene delivery to kidney.
• Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats.
• Late postoperative complication of the foldable lens implantation: opacification of the intraocular lenses.
• Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
• Tissue array technique for p53 expression in human ovarian neoplasms.
• [A case of cerebral schistosomiasis misdiagnosed as brain tumor]
• [Chromosome t (8; 21) and t (15; 17) in a patient with acute myeloid leukemia]
• [Construction of a subtracted cDNA library of differentially expressed genes in human normal liver tissue and primary hepatocellular carcinoma tissue]
• [Control genes of chondrocyte apoptosis in osteoarthritic articular cartilage]
• [Effects of cactus, alove veral, momorcica charantia on reducing the blood glucose of diabetic mice]
• [Force-dependent effects of interleukin-8 gene expression in endothelial cells exposed on fluid shear stress]
• [Human cytomegalovirus inhibits the proliferation of CFU-MK in vitro]
• [Immunorelated pancytopenia]
• [Intro-extro cranial approach treat serious post fronto-orbital fracture deformities]
• [Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study]
• [Patients of severe acute respiratory syndrome with hypoxemia treated by anisodamine]
• [Polylactic acid combined with recombinant human bone morphogenetic protein and basic fibroblast growth factor to repair the mandibular defects in rabbits]
• [Protection on proliferation of intestinal epithelial cells against hypoxia-reoxygenation through recombinant heat shock protein 70 adenovirus transfection]
• [Relationship between the changes of beta2-microglobulin in blood and urine and kidney involvements in children with pneumonia]
• [Research progress on the signal transduction and the molecular regulation of oocyte meiotic maturation]
• [Schistosomiasis investigation at 4 villages of Yangjiayuan during a flood in 1999]
• [Second-line Hycamtin in the treatment of lung cancer]
• [Sequential intensified immunosuppressive therapy combining with hematopoietic growth factors in the treatment of severe aplastic anemia]
• [Seventy degrees lateral decubital intraperiteanal laparoscopic adrenal surgery]
• [Studies on photochemical disinfectant enamelled-ware of toxicity experiments]
• [Study on the transformation from myelodysplastic syndromes into acute leukemias]
• [Surgical management of sacrococcygeal chordomas]
• [The genetic characteristic of HLA-DRB1 locus in the Jiangsu-Zhejiang-Shanghai Han population and a comparison of its frequency distribution with that of other populations]
• [The postburn changes in gastric mucosal blood flow and Na+-K+-ATPase activity and their effects on gastric transmucosal potential difference in severely scalded rats]