Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study.

Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study. Research Abstract Details 

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Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study. Abstract Text:

Irene Y Tsai,J Angelo Green,Masahiro Kimura,Bruce Jacobson,Thomas P Russell,

Transparent substrates having heterogeneities ranging from nanometer to micrometer lateral length scale were fabricated to study cell migration. The surfaces were generated using thin films of block copolymers and homopolymer blends on ultra smooth transparent polyethylene terephthalate films. Results show that the lateral size scale of the surface heterogeneities affects fibroblast (NIH-3T3) adhesion, spreading and motility. More specifically, fibroblasts migrate faster on micron-sized than on nanometer-sized heterogeneities. Cell movements and morphology on the micron patterned surfaces resemble cells cultured in a 3D environment. These surfaces, therefore, can potentially be utilized as models to study cell behavior in physiologically relevant conditions which can add to our fundamental understanding of cell-substrate interactions and facilitate development of surfaces for medical devices.

Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study. Publishing Authors By Initials

IY Tsai,JA Green,M Kimura,B Jacobson,TP Russell,

For similar natural sciences: chemistry: chemistry, physical: surface properties research abstracts see: natural sciences: chemistry: chemistry, physical: surface properties research

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MEDLINE DATE:

Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomedical materials research. Part A

VOLUME: 80

Page Numbers: 509-12

Journal Abbreviation:

ISSN: 1549-3296

DAY: 3

MONTH: Feb

YEAR: 2007

Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study. Keywords Mesh Terms:

KEYWORDS: Surface Properties

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study. Information

Substance Name: Polymers

Registry Number: 0

Grant and Affiliation Information for Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study.

AFFILIATION: Polymer Science and Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32-GM08515

ACRONYM: GM

MEDLINETA: J Biomed Mater Res A

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